Article thumbnail
Location of Repository

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells

By Martina Düfer, Belinda Gier, Daniela Wolpers, Peter Krippeit-Drews, Peter Ruth and Gisela Drews
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2712794
Provided by: PubMed Central

Suggested articles

Citations

  1. A human intermediate conductance calcium-activated potassium channel.
  2. A new generation of Ca 2 indicators with greatly improved fluorescence properties.
  3. (2007). Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes Obes Metab
  4. (1998). Ahring PK. Characterization of the cloned human intermediate-conductance Ca 2-activated K channel.
  5. (1996). Amperometric detection of quantal secretion from patch-clamped rat pancreatic beta-cells.
  6. (1998). An intermediate conductance K channel in the cell membrane of mouse intestinal smooth muscle.
  7. (2001). Benzimidazolone activators of chloride secretion: potential therapeutics for cystic fibrosis and chronic obstructive pulmonary disease. J Pharmacol Exp Ther
  8. (1990). Biophysics and physiology of ATP-regulated K channels (KATP).
  9. Blunted IgE-mediated activation of mast cells in mice lacking the Ca 2-activated K channel KCa3.1.
  10. Calcium action potentials and potassium permeability activation in pancreatic beta-cells.
  11. (1990). Calcium channels, potassium channels, and voltage dependence of arterial smooth muscle tone.
  12. Calcium-activated potassium channels and the regulation of vascular tone.
  13. (2007). Cell cycle-dependent expression of potassium channels and cell proliferation in rat mesenchymal stem cells from bone marrow. Cell Prolif
  14. (1998). Characterization of a Ca 2-activated K current in insulin-secreting murine betaTC-3 cells.
  15. (1991). Charybdotoxin-sensitive KCa channel is not involved in glucose-induced electrical activity in pancreatic beta-cells.
  16. (1996). Cloning of human pancreatic islet large conductance Ca 2-activated K channel (hSlo) cDNAs: evidence for high levels of expression in pancreatic islets and identification of a flanking genetic marker. Diabetologia
  17. Crosstalk between membrane potential and cytosolic Ca 2 concentration in beta cells from
  18. (2006). DCEBIO stimulates Cl secretion in the mouse jejunum.
  19. (1998). Defective insulin secretion and enhanced insulin action in KATP channel-deficient mice.
  20. (1990). Delayed rectifying and calcium-activated K channels and their significance for action potential repolarization in mouse pancreatic beta-cells.
  21. Design of a potent and selective inhibitor of the intermediate-conductance Ca 2-activated K channel, IKCa1: a potential immunosuppressant.
  22. Drug-induced hypoglycemic coma in 102 diabetic patients.
  23. Effects of compounds that influence IK (KCNN4) channels on afterhyperpolarizing potentials, and determination of IK channel sequence, in guinea pig enteric neurons.
  24. Electrophysiological properties of a novel Ca 2-activated K channel expressed in human osteoblasts.
  25. (1989). Electrophysiology of the pancreatic beta-cell. Prog Biophys Mol Biol
  26. (1996). Expression and function of pancreatic beta-cell delayed rectifier K channels: role in stimulus-secretion coupling.
  27. Expression of a rapid, low-voltage threshold K current in insulin-secreting cells is dependent on intracellular calcium buffering.
  28. (2004). Expression of voltage-gated potassium channels in human and rhesus pancreatic islets. Diabetes
  29. Glucose-dependent regulation of rhythmic action potential firing in pancreatic beta-cells by KATP-channel modulation.
  30. (2009). GUIDE study: double-blind comparison of once-daily gliclazide MR and glimepiride in type 2 diabetic patients.
  31. (2006). Impaired endothelium-derived hyperpolarizing factor-mediated dilations and increased blood pressure in mice deficient of the intermediateconductance Ca 2-activated K channel. Circ Res
  32. (2009). Inhibition of Kv2.1 voltage-dependent K channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.
  33. Inositol trisphosphate-dependent periodic activation o faC a 2-activated K conductance in glucose-stimulated pancreatic beta-cells.
  34. (2005). International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. Pharmacol Rev
  35. (1974). Membrane potential of beta-cells in pancreatic islets. Pflu ¨gers Arch
  36. (1988). Metabolic regulation of the KATP and a maxi-KV channel in the insulin-secreting RINm5F cell.
  37. (2004). Oscillations of membrane potential and cytosolic Ca 2 concentration in SUR1 -/- beta cells. Diabetologia
  38. Overnight culture unmasks glucoseinduced insulin secretion in mouse islets lacking ATP-sensitive K channels by improving the triggering Ca 2 signal.
  39. Pharmacological properties and functional role of Kslow current in mouse pancreatic beta-cells: SK channels contribute to Kslow tail current and modulate insulin secretion.
  40. Physiological roles of the intermediate conductance, Ca 2-activated potassium channel Kcnn4.
  41. regulates PKA-independent cAMP-induced granule priming in mouse pancreatic B-cells.
  42. Regulation of Kv1.3 channels in activated human T lymphocytes by Ca 2-dependent pathways.
  43. (1999). Renstro ¨m E, Rorsman P. Activation of Ca 2-dependent K channels contributes to rhythmic firing of action potentials in mouse pancreatic beta cells.
  44. Renstro ¨m E. Perchlorate stimulates insulin secretion by shifting the gating of L-type Ca 2 currents in mouse pancreatic B-cells towards negative potentials. Pflu ¨gers Arch 2001;441:
  45. (2007). Role of cholinergic-activated
  46. (1990). Role of voltage- and Ca 2-dependent K channels in the control of glucose-induced electrical activity in pancreatic B-cells. Pflu ¨gers Arch
  47. (1990). Simultaneous recordings of glucose dependent electrical activity and ATP-regulated K -currents in isolated mouse pancreatic beta-cells.
  48. SK4 encodes intermediate conductance Ca 2-activated K channels in mouse urinary bladder smooth muscle cells.
  49. Small-conductance calcium-activated K channels are expressed in pancreatic islets and regulate glucose responses.
  50. Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose.
  51. Sur1 knockout mice: a model for KATP channel-independent regulation of insulin secretion.
  52. (2001). The expression and regulation of depolarization-activated K channels in the insulin-secreting cell line INS-1. Pflu ¨gers Arch
  53. The hSK4 (KCNN4) isoform is the Ca 2-activated K channel (Gardos channel) in human red blood cells.
  54. Tight coupling between electrical activity and exocytosis in mouse glucagon-secreting alpha-cells.
  55. Voltage-dependent Ca 2-channel block by openers of intermediate and small conductance Ca 2-activated K channels in urinary bladder smooth muscle cells.
  56. Voltage-dependent K channels in pancreatic beta cells: role, regulation and potential as therapeutic targets.
  57. (1991). Widespread synchronous [Ca 2]i oscillations due to bursting electrical activity in single pancreatic islets. Pflu ¨gers Arch

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.