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Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

By Seokjoon Lee, Sangtae Oh, Gab-Man Park, Tong-Soo Kim, Jae-Sook Ryu and Han-Kyu Choi

Abstract

Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10β-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin

Topics: Brief Communication
Publisher: The Korean Society for Parasitology
OAI identifier: oai:pubmedcentral.nih.gov:2712013
Provided by: PubMed Central
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