Article thumbnail
Location of Repository

Antimalarial activity of thiophenyl- and benzenesulfonyl-dihydroartemisinin

By Seokjoon Lee, Sangtae Oh, Gab-Man Park, Tong-Soo Kim, Jae-Sook Ryu and Han-Kyu Choi


Each diastereomer of 10-thiophenyl- and 10-benzenesulfonyl-dihydroartemisinin was synthesized from artemisinin in three steps, and screened against chloroquine-resistance and chloroquine-sensitive Plasmodium falciparum. Three of the four tested compounds were found to be effective. Especially, 10β-benzenesulfonyl-dihydroartemisinin showed stronger antimalarial activity than artemisinin

Topics: Brief Communication
Publisher: The Korean Society for Parasitology
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.