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Effect of administration of rifampicin on the adrenocortical function in patients with pulmonary tuberculosis

By G Raghupati Sarma, Chandra Immanuel, P V Krishnamurthy, Rani Balasubramanian, Geetha Ramachandran and R Prabhakar


Adrenocortical function was studied on admission and during treatment in 57 newlydiagnosed patients with pulmonary tuberculosis, 16 of whom were treated with a daily regimen containing Rifampicin (R-7), 22 with a twiceweekly regimen containing the same drug (R-Z) and 19 with a daily regimen that did not contain Rifampicin (NR-7). In patients on daily treatment (R-7 and NR-7), there was a slight increase in plasma cortisol at 1 week followed by a decline; while the mean level at 4 weeks was similar to that on admission in the R-7 patients, that in the NR-7 patients was significantly lower (P < 0.01). No change was observed in the R-2 patients. A positive response to tetracosactrin was observed in the 7 R-7, 14 R-Z and 7 NR-7 patients on admission and in 6, 14 and 14, respectively at 4 weeks. The increase in the proportion of positive responders in the NH-7 patients was significant (P = 0.05). On admission, the diurnal rhythm of the release of cortisol, as assessed by changes in salivary cortisol, was disturbed in the patients with an evening rise in the cortisol levels; it had, however, reverted to a near-normal pattern after 2 months of treatment in all 3 groups of patients

Topics: Biochemical,Clinical and Pharmacological
Publisher: Tuberculosis Association of India
Year: 1992
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