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Rab4b Is a Small GTPase Involved in the Control of the Glucose Transporter GLUT4 Localization in Adipocyte

By Vincent Kaddai, Teresa Gonzalez, Frédérique Keslair, Thierry Grémeaux, Stéphanie Bonnafous, Jean Gugenheim, Albert Tran, Philippe Gual, Yannick Le Marchand-Brustel and Mireille Cormont
Topics: Research Article
Publisher: Public Library of Science
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Provided by: PubMed Central

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  2. (2001). Adipocytes exhibit abnormal subcellular distribution and translocation of vesicles containing glucose transporter 4 and insulin-regulated aminopeptidase in type 2 diabetes mellitus: implication regarding defects in vesicle trafficking.
  3. (1999). Analysis of amino and carboxy terminal GLUT-4 targeting motifs in 3T3-L1 adipocytes using an endosomal ablation technique.
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  6. (2005). CD2AP, Rabip4 and Rabip49: analysis of interaction with Rab4a and regulation of endosomes morphology.
  7. (2003). CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl.
  8. (2005). Characterization of the role of the Rab GTPase-activating protein AS160 in insulin-regulated GLUT4 trafficking.
  9. (1996). Compartment ablation analysis of the insulin-responsive glucose transporter (GLUT4) in 3T3-L1 adipocytes.
  10. (1997). Compartment-ablation studies of GLUT4 distribution in adipocytes: evidence for multiple intracellular pools.
  11. (1998). Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance.
  12. (2001). Expression of a prenylation-deficient Rab4 inhibits the GLUT4 translocation induced by active phosphatidylinositol 3-kinase and protein kinase B.
  13. (2000). Expression of a prenylationdeficient Rab4 interferes with propagation of insulin signaling through insulin receptor substrate-1.
  14. (2007). Gapex-5, a Rab31 guanine nucleotide exchange factor that regulates Glut4 trafficking in adipocytes.
  15. (2002). GLUT4 retention in adipocytes requires two intracellular insulin-regulated transport steps.
  16. (2002). Impaired (‘diabetic’) insulin signaling and action occur in fat cells long before glucose intolerance–is insulin resistance initiated in the adipose tissue?
  17. (2006). Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.
  18. (2006). Inhibition of p38MAPK increases adipogenesis from embryonic to adult stages.
  19. (1993). Insulin and okadaic acid induce Rab4 redistribution in adipocytes.
  20. (2004). Insulin increases cell surface GLUT4 levels by dose dependently discharging GLUT4 into a cell surface recycling pathway.
  21. (1996). Insulin induces a change in Rab5 subcellular localization in adipocyte independently of phosphatidylinositol 3-kinase activation.
  22. (2003). Insulin-induced GLUT4 translocation involves protein kinase C-lambda-mediated functional coupling between Rab4 and the motor protein kinesin.
  23. (2007). Interleukin-1{beta]-induced insulin resistance in adipocytes through down regulation of IRS-1 expression.
  24. (2007). Klip A
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  27. (2002). Mosaic organization of the endocytic pathway.
  28. (1993). Multiple defects in the adipocyte glucose transport system cause cellular insulin resistance in gestational diabetes. Heterogeneity in the number and a novel abnormality in subcellular localization of GLUT4 glucose transporters.
  29. (1996). Phosphatidylinositol 3-kinase acts at an intracellular membrane site to enhance GLUT4 exocytosis in 3T3-L1 cells.
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  31. (2005). Rab proteins, connecting transport and vesicle fusion.
  32. (2007). Rab10, a target of the AS160 Rab GAP, is required for insulin-stimulated translocation of GLUT4 to the adipocyte plasma membrane.
  33. (2000). Rab11 is associated with GLUT4-containing vesicles and redistributes in response to insulin.
  34. (2007). Rapid preparation of a plasma membrane fraction from adipocytes and muscle cells: application to detection of translocated glucose transporters 4 on the plasma membrane.
  35. (2002). Regulated transport of the glucose transporter GLUT4.
  36. (1999). Regulation of membrane transport through the endocytic pathway by rabGTPases.
  37. (2008). The nitric oxide-donating derivative of acetylsalicylic acid, NCX 4016, stimulates glucose transport and glucose transporters translocation in 3T3-L1 adipocytes.
  38. (2006). The Rab4 effector Rabip4 plays a role in intracellular trafficking of Glut 4 in 3T3-L1 adipocytes.
  39. (2001). The role of small G-proteins in the regulation of glucose transport.
  40. (1997). The small guanosine triphosphate-binding protein Rab4 is involved in insulininduced GLUT4 translocation and actin filament rearrangement in 3T3-L1 cells.
  41. (2007). Tissue-specific alterations of glucose transport and molecular mechanisms of intertissu communication in obesity and type 2 diabetes.

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