Article thumbnail
Location of Repository

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

By Fiona E McRonald, Mark R Morris, Dean Gentle, Laura Winchester, Dilair Baban, Jiannis Ragoussis, Noel W Clarke, Michael D Brown, Takeshi Kishida, Masahiro Yao, Farida Latif and Eamonn R Maher
Topics: Research
Publisher: BioMed Central
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2006). A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta.
  2. (2008). CpG island methylator phenotype (CIMP) in cancer: causes and implications. Cancer Lett
  3. (2001). ER: Epigenetic inactivation of the RASSF1A 3p21.3 tumor suppressor gene in both clear cell and papillary renal cell carcinoma. Cancer Res
  4. (2008). ER: Functional epigenomics approach to identify methylated candidate tumour suppressor genes in renal cell carcinoma.
  5. (2002). ER: Identification of cyclin D1 and other novel targets for the von Hippel-Lindau tumor suppressor gene by expression array analysis and investigation of cyclin D1 genotype as a modifier in von Hippel-Lindau disease. Cancer Res
  6. (1998). ER: Inactivation of the von Hippel-Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: evidence for a VHL-independent pathway in clear cell renal tumourigenesis. Genes Chromosomes Cancer
  7. (1994). ER: Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22.
  8. (2003). ER: Multigene methylation analysis of Wilms' tumour and adult renal cell carcinoma. Oncogene
  9. (2005). ER: Tumor suppressor activity and epigenetic inactivation of hepatocyte growth factor activator inhibitor type 2/SPINT2 in papillary and clear cell renal cell carcinoma. Cancer Res
  10. (2007). Gene methylation and early detection of genitourinary cancer: the road ahead. Nat Rev Cancer
  11. (1994). Identification of the von Hippel-Lindau disease tumor suppressor gene.
  12. (2006). JB: High-throughput DNA methylation profiling using universal bead arrays. Genome Res
  13. (2007). Jerónimo C: Quantitative promoter methylation analysis of multiple cancer-related genes in renal cell tumors.
  14. (2006). KT: Examination of a CpG island methylator phenotype and implications of methylation profiles in solid tumors. Cancer Res
  15. (1994). Linehan WM: Mutations of the VHL tumour suppressor gene in renal carcinoma.
  16. (2008). LS: Kidneytargeted Birt-Hogg-Dube gene inactivation in a mouse model: Erk1/2 and Akt-mTOR activation, cell hyperproliferation, and polycystic kidneys.
  17. (2003). Ohno S: Loss of von HippelLindau protein causes cell density dependent deregulation of CyclinD1 expression through hypoxia-inducible factor. Oncogene
  18. (2006). PJ: Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer. Cancer Res
  19. (2004). Promoter hypermethylation profile of kidney cancer. Clin Cancer Res
  20. (2006). PW: CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet
  21. (1998). Reeve AE: E-cadherin germline mutations in familial gastric cancer. Nature
  22. (2005). Rettig MB: Mechanism of von Hippel-Lindau proteinmediated suppression of nuclear factor kappa B activity. Mol Cell Biol
  23. (2007). RP: Molecular mechanisms underlying the MiT translocation subgroup of renal cell carcinomas. Cytogenet Genome Res
  24. (2006). SJ: Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band. Nat Genet
  25. (2008). Teh BT: Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo. Cancer Res
  26. (2008). The French Kidney Cancer Study Group, Baba S, Teh BT: Identification of copy number alterations and its association with pathological features in clear cell and papillary RCC. Cancer Lett
  27. (2007). Women with Saethre-Chotzen syndrome are at increased risk of breast cancer. Genes Chromosomes Cancer

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.