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Regulation of Episomal Gene Expression by KRAB/KAP1-Mediated Histone Modifications▿

By Isabelle Barde, Elisa Laurenti, Sonia Verp, Anna Claire Groner, Christopher Towne, Viviane Padrun, Patrick Aebischer, Andreas Trumpp and Didier Trono


KAP1 is an essential cofactor of KRAB zinc finger proteins, a family of vertebrate-specific epigenetic repressors of largely unknown functions encoded in the hundreds by the mouse and human genomes. So far, KRAB/KAP1-mediated gene regulation has been studied within the environment of chromosomal DNA. Here we demonstrate that KRAB/KAP1 regulation is fully functional within the context of episomal DNA, such as adeno-associated viral and nonintegrated lentiviral vectors, and is correlated with histone modifications typically associated with this epigenetic regulator

Topics: Gene Delivery
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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