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Effect of Procainization of Ventromedial Nucleus of Hypothalamus on the Feeding Behavior of Rats

By Rajesh Yadav, Manjula Suri, Rashmi Mathur and Suman Jain


Bilateral lesions in the Ventromedial nucleus of hypothalamus (VMH) cause hyperphagia and a preference for high lipid, high carbohydrate diet. Reversible lesion by procaine microinfusion produces a decrease in serum glucose and immunoreactive insulin levels. In the present study the effect of procaine microinfusion on feeding behavior and taste preference was observed. 5 h and 24 h food intake, water intake and weekly body weight of the rats was measured. Three bottle preference test was used to study the diet preferences. The 24 h food intake was found to be significantly more on 1st, 2nd and 3rd day (41 ± 6.03, 38.83 ± 6.17 and 33.66 ± 5.88 g/day, respectively) of procaine injection. There was also a significant increase in food intake at 0.25 h (4.166 ± 2.04 g) and 1 h (5 ± 0 g) as compared to saline group (0 ± 0 g at 0.25 h and 0.83 ± 2.04 g at 1 h). Post procaine water intake and body weight for seven days was not statistically significantly when compared to pre-lesion values. In the three bottles preference test, after procaine microinfusion there was a significantly increased preference for 20% sucrose and 0.15% saccharin than quinine and citric acid. The results suggest that bilateral procainization of VMH produces a transient increase in food intake and enhance preference for sweet tasting substances

Topics: Original Article
Publisher: the Society for Free Radical Research Japan
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