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Lipin proteins and metabolic homeostasis

By Karen Reue and Jennifer R. Dwyer


The lipin protein family, consisting of three members, was first identified early this century. In the last few years, the lipin proteins have been shown to have important roles in glycerolipid biosynthesis and gene regulation, and mutations in the corresponding genes cause lipodystrophy, myoglobinuria, and inflammatory disorders. Here, we review some of the progress toward elucidating the molecular and physiological functions of the lipin proteins

Topics: Metabolism
Publisher: American Society for Biochemistry and Molecular Biology
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Provided by: PubMed Central
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