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New technologies for delineating and characterizing the lipid exome: prospects for understanding familial combined hyperlipidemia

By Stuart D. Horswell, Helen E. Ringham and Carol C. Shoulders

Abstract

This review summarizes the progress made in cutting through the biological and genetic complexity of the Gordian knot that is familial combined hyperlipidemia. We particularly focus on how the application of new genomic technologies, especially massively parallel sequencing and high-throughput genotyping platforms, promise to accelerate the gene discovery process in this common, highly atherogenic disorder, with important diagnostic and therapeutic implications

Topics: Atherogenesis
Publisher: American Society for Biochemistry and Molecular Biology
OAI identifier: oai:pubmedcentral.nih.gov:2674706
Provided by: PubMed Central
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