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Aberrations in T-Cell Subpopulations in Patients with Psoriasis and Psoriatic Arthritis

By Dafna D. Gladman, Edward C. Keystone and Ricky K. Schacter

Abstract

Peripheral blood B-cell subpopulations and B-cell numbers from 25 patients with uncomplicated psoriasis and 22 patients with psoriasis arthritis were compared with those of 24 age- and sex-matched healthy volunteers and 11 patients with radiologically defined erosive osteoarthritis. The numbers of early and late rosettes were found to be reduced in patients with psoriasis, with and without arthritis, while the total T-cell population (measured by aminoethyithiouronium bromide-rosettes) was found to be normal. There was no difference in the number of B cells between psoriasis patients and controls. Dose-response studies of mitogen stimulation with phytohemagglutinin and concanavalin A revealed generally higher proliferative responses in the psoriatic patients only at supraoptimal concentrations. The pokeweed mitogen response, however, was reduced in patients with cutaneous psoriasis and increased in patients with psoriatic arthritis. These studies further support the concept of an immunologic imbalance in lymphocyte populations from patients with psoriasis and psoriatic arthritis

Publisher: The Society for Investigative Dermatology, Inc. Published by Elsevier Inc.
Year: 1983
DOI identifier: 10.1111/1523-1747.ep12534656
OAI identifier:

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