Skip to main content
Article thumbnail
Location of Repository

DEAR1 Is a Dominant Regulator of Acinar Morphogenesis and an Independent Predictor of Local Recurrence-Free Survival in Early-Onset Breast Cancer

By Steven T. Lott, Nanyue Chen, Dawn S. Chandler, Qifeng Yang, Luo Wang, Marivonne Rodriguez, Hongyan Xie, Seetharaman Balasenthil, Thomas A. Buchholz, Aysegul A. Sahin, Katrina Chaung, Baili Zhang, Shodimu-Emmanu Olufemi, Jinyun Chen, Henry Adams, Vimla Band, Adel K. El-Naggar, Marsha L. Frazier, Khandan Keyomarsi, Kelly K. Hunt, Subrata Sen, Bruce Haffty, Stephen M. Hewitt, Ralf Krahe and Ann McNeill Killary

Abstract

Ann Killary and colleagues describe a new gene that is genetically altered in breast tumors, and that may provide a new breast cancer prognostic marker

Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2673042
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (1997). A candidate gene for familial Mediterranean fever.
    2. (1989). A newly established metastatic breast tumor cell line with integrated amplified copies of ERBB2 and double minute chromosomes.
    3. (1992). A novel zinc finger coiled-coil domain in a family of nuclear proteins.
    4. (1995). Age as a prognostic factor in breast cancer: relationship to pathologic and biologic features.
    5. (1993). Age as prognostic factor in premenopausal breast carcinoma.
    6. (1994). Alterations in epithelial polarity and the pathogenesis of disease states.
    7. (1987). An improved method for prenatal diagnosis of genetic diseases by analysis of amplified DNA sequences. Application to hemophilia A.
    8. (1997). Ancient missense mutations in a new member of the RoRet gene family are likely to cause familial Mediterranean fever.
    9. (2006). beta4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.
    10. (2002). beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.
    11. (2003). Cancer statistics,
    12. (2003). CEACAM1-4S, a cell– cell adhesion molecule, mediates apoptosis and reverts mammary carcinoma cells to a normal morphogenic phenotype in a 3D culture.
    13. (2008). CHD5 is a tumor suppressor at human 1p36.
    14. (1992). Chromosome 1 alterations in breast cancer: allelic loss on 1p and 1q is related to lymphogenic metastases and poor prognosis.
    15. (1992). Definition of a tumor suppressor gene within human chromosome 3p21-p22. Proc Natl Acad Sci
    16. (2005). Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells.
    17. (2008). Deregulation of Scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma.
    18. (2002). Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.
    19. (2001). ErbB2, but not ErbB1, reinitiates proliferation and induces luminal repopulation in epithelial acini.
    20. (2007). Fine mapping of the NRC-1 tumor suppressor locus within chromosome 3p12.
    21. (2000). Gene encoding a new RING-B-box-Coiled-coil protein is mutated in mulibrey nanism.
    22. (2001). Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications.
    23. (1992). Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.
    24. (1999). Linkage analysis and loss of heterozygosity for chromosome arm 1p in familial breast cancer.
    25. (1998). Local recurrence in the conservatively treated breast cancer patient: a correlation with age and family history.
    26. (1995). Local recurrences and distant metastases after conservative breast cancer treatments: partly independent events.
    27. (1999). Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival.
    28. (2003). Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures.
    29. (2004). Mutations of the PML tumor suppressor gene in acute promyelocytic leukemia.
    30. (2000). New mutations in MID1 provide support for loss of function as the cause of X-linked Opitz syndrome.
    31. (1994). Oncogenes and epithelial cell transformation.
    32. (1997). Opitz G/BBB syndrome, a defect of midline development, is due to mutations in a new RING finger gene on Xp22.
    33. (2002). Outcome of conservatively managed early-onset breast cancer by BRCA 1/2 status.
    34. (2008). Outcomes in young women with breast cancer of triple-negative phenotype: the prognostic significance of CK19 expression.
    35. (2006). Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control.
    36. (1998). Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3p12.
    37. (2004). Polarity and proliferation are controlled by distinct signaling pathways downstream of PI3-kinase in breast epithelial tumor cells.
    38. (1991). Prognostic factors for local recurrence in the conservatively treated breast cancer patient: a cautious interpretation of the data.
    39. Recht A (2004) Young age and outcome for women with early-stage invasive breast carcinoma.
    40. (1998). Reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology.
    41. (1997). Reversion of the malignant phenotype of human breast cells in threedimensional culture and in vivo by integrin blocking antibodies.
    42. (1992). RFP is a DNA binding protein associated with the nuclear matrix.
    43. (1998). RING fingers and B-boxes: zinc-binding protein-protein interaction domains.
    44. (2003). Sensitive and quantitative universal pyrosequencing methylation analysis of CpG sites.
    45. (1991). Significance of ipsilateral breast tumour recurrence after lumpectomy.
    46. (1992). Structure, localization and transcriptional properties of two classes of retinoic acid receptor alpha fusion proteins in acute promyelocytic leukemia (APL): structural similarities with a new family of oncoproteins.
    47. (1991). The cloning and characterization of a maternally expressed novel zinc finger nuclear phosphoprotein (xnf7) in Xenopus laevis.
    48. (1999). The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation.
    49. (1994). The influence of young age on outcome in early stage breast cancer.
    50. (1995). The Nterminal part of TIF1, a putative mediator of the ligand-dependent activation function (AF-2) of nuclear receptors, is fused to B-raf in the oncogenic protein T18.
    51. (1993). The RING finger. A novel protein sequence motif related to the zinc finger.
    52. (2002). The role of apoptosis in creating and maintaining luminal space within normal and oncogene-expressing mammary acini.
    53. (2001). The tripartite motif family identifies cell compartments.
    54. (2003). To create the correct microenvironment: three-dimensional heterotypic collagen assays for human breast epithelial morphogenesis and neoplasia.
    55. (1990). Tumor progression in four mammary epithelial cell lines derived from the same patient.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.