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Correction for phylogeny, small number of observations and data redundancy improves the identification of coevolving amino acid pairs using mutual information

By Cristina Marino Buslje, Javier Santos, Jose Maria Delfino and Morten Nielsen


Motivation: Mutual information (MI) theory is often applied to predict positional correlations in a multiple sequence alignment (MSA) to make possible the analysis of those positions structurally or functionally important in a given fold or protein family. Accurate identification of coevolving positions in protein sequences is difficult due to the high background signal imposed by phylogeny and noise. Several methods have been proposed using MI to identify coevolving amino acids in protein families

Topics: Original Papers
Publisher: Oxford University Press
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Provided by: PubMed Central
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