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Phosphodiesterase 4D Gene and Risk of Noncardiogenic Ischemic Stroke in a Korean Population

By Myeong-Kyu Kim, Jun-Tae Kim, Sung-Min Choi, Seung-Han Lee, Man-Seok Park and Ki-Hyun Cho

Abstract

Recently published studies from different populations provide apparently conflicting evidence on the association between the phosphodiesterase 4D (PDE4D) gene and ischemic stroke. The relationship between a representative PDE4D genotype and ischemic stroke was explored in a case-control study of 205 consecutive Korean patients with noncardiogenic ischemic stroke and 103 healthy controls who were neurologically and radiologically proven to be stroke-free. We selected and genotyped a PDE4D single nucleotide polymorphism (SNP 41, rs152312) as a candidate marker for susceptibility to ischemic stroke because SNP 41 has shown the most significant association with stroke in both a meta-analysis and the original Icelandic study of the PDE4D gene. No significant difference was observed between the cases and controls in the distribution of the PDE4D SNP 41 genotypes. The results from the adjusted conditional logistic regression analysis (adjusted for age, hypertension, diabetes and smoking status) showed no significant association between PDE4D SNP 41 genotypes and an increased risk of noncardiogenic ischemic stroke. The PDE4D gene is not a major risk factor for noncardiogenic ischemic stroke in a Korean population, which supports the recent evidence suggesting that the causative genetic variants of ischemic stroke may differ across populations

Topics: Original Article
Publisher: The Korean Academy of Medical Sciences
OAI identifier: oai:pubmedcentral.nih.gov:2672133
Provided by: PubMed Central
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    Citations

    1. (2004). Genetics of cerebrovascular disease. Stroke
    2. (2003). Genetics of common polygenic stroke.
    3. (1997). Modeling of risk factors for ischemic stroke. The Willis Lecture. Stroke
    4. (2005). Phosphodiesterase 4D gene, ischemic stroke, and asymptomatic carotid atherosclerosis. Stroke
    5. (2003). The gene encoding phosphodiesterase 4D confers risk of ischemic stroke.
    6. (2006). Trends in incidence, lifetime risk, severity, and 30-day mortality of stroke over the past 50 years. JAMA

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