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Patterns of prefrontal dysfunction in alcoholics with and without Korsakoff’s syndrome, patients with Parkinson’s disease, and patients with rupture and repair of the anterior communicating artery

By Courtney L Dirksen, Julie A Howard, Alice Cronin-Golomb and Marlene Oscar-Berman

Abstract

This study compared patterns of frontal-lobe dysfunction in alcoholics with Korsakoff’s syndrome (KS: n = 9), non-Korsakoff alcoholics (AL: n = 28), patients with Parkinson’s disease (PD: n = 18), and patients with rupture and repair of the anterior communicating artery (ACoA: n = 4) relative to healthy non-neurological control (NC) participants (n = 70). The tests administered were sensitive to functions of dorsolateral prefrontal and orbito-frontal subsystems. Measures included perseverative errors on the Wisconsin Card Sorting Test (WCST-pe), errors on object alternation (OA), errors on Trails B, number of words generated on the Controlled Oral Word Association Test (COWAT), and number of categories completed on the WCST (WCST-cc). KS patients were as impaired as AL participants on orbitofrontal measures and, on dorsolateral prefrontal measures, were impaired relative to AL participants, whose performance did not differ from controls. Patients with PD also were impaired on tests of orbitofrontal and dorsolateral prefrontal functioning but to a lesser extent than the KS patients. Moreover, most of the PD deficits were driven by the impaired performance of patients whose initial symptoms were on the right side of the body. The ACoA patients were significantly impaired on tests of orbitofrontal but not dorsolateral prefrontal functioning relative to the control group. Together, the results confirm different patterns of frontal-system impairments in patient groups having compromised frontal lobe functioning consequent to varying etiologies

Topics: Original Research
Publisher: Dove Medical Press
OAI identifier: oai:pubmedcentral.nih.gov:2671822
Provided by: PubMed Central
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    Citations

    1. (1997). [123I]FP-CIT SPECT shows a pronounced decline of striatal dopamine transporter labeling in early and advanced Parkinson’s disease.
    2. (1998). A compendium of neuropsychological tests. 2nd ed.
    3. (1960). A rating scale for depression.
    4. (2001). A revised neuroanatomy of frontal-subcortical circuits.
    5. (1948). A simple objective technique for measuring fl exibility in thinking.
    6. (1997). Alcoholic Korsakoff’s syndrome.
    7. (2003). Alcoholism and the brain: An overview. Alcohol Res Health,
    8. (1989). Asymmetry of substantia nigra neuronal loss in Parkinson’s disease and its relevance to the mechanism of levodopa related motor fl uctuations.
    9. (1986). Bilateral frontal lobe disease and selective delayed response defi cits in humans.
    10. (2000). Binding of [99mTc] TRODAT-1 to dopamine transporters in patients with Parkinson’s disease and in healthy volunteers.
    11. (2000). Cerebellar volume decline in normal aging, alcoholism, and Korsakoff’s syndrome: Relation to ataxia.
    12. (1989). Cognitive impairments associated with early Parkinson’s disease.
    13. (1980). Comparative neuropsychology and Korsakoff’s syndrome. II: Two-choice visual discrimination learning.
    14. (2004). Comparisons of Korsakoff and non-Korsakoff alcoholics on neuropsychological tests of prefrontal brain functioning. Alcohol Clin Exp Res,
    15. (1995). Complementary positron emission tomographic studies of the striatal dopaminergic system in Parkinson’s disease.
    16. (1991). Core text of neuroanatomy. Baltimore, MD: Williams and Wilkins.Neuropsychiatric Disease and Treatment 2006:2(3) 339 Patterns of prefrontal dysfunction
    17. (2004). Development of orbitofrontal function: Current themes and future directions. Brain Cognit (Special Issue: Development of orbitofrontal function),
    18. (2005). Dissociable elements of human foresight: a role for the ventromedial frontal lobes in framing the future, but not in discounting future rewards.
    19. (1998). Drug-naïve patients with Parkinson’s disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [123I]beta-CIT SPECT.
    20. (1993). Eighth special report to the US Congress on alcohol and health.
    21. (1998). Executive cognitive functions as mediators of alcohol-related aggression. Alcohol Alcohol,
    22. (2002). Executive control function: A review of its promise and challenges for clinical research.
    23. (2002). Fractionation of the supervisory system.
    24. (2001). Frontal lobe changes in alcoholism: A review of the literature. Alcohol Alcohol,
    25. (1986). Frontal lobe dysfunction in Parkinson’s disease.
    26. (1991). Frontal lobe function and dysfunction. NY:
    27. (1997). Frontal lobe volume loss observed with magnetic resonance imaging in older chronic alcoholics. Alcohol Clin Exp Res,
    28. (2003). Frontal-striatal circuit functions: Context, sequence, and consequence.
    29. (2001). Frontal-subcortical circuits in psychiatric and neurological disorders.
    30. (1995). Interpreting the confabulations of geriatric medical inpatients: two case studies.
    31. (1997). Memory and executive functions in amnesic and non-amnesic patients with aneurysms of the anterior communicating artery.
    32. (1975). Mini-mental State.’ A practical method for grading the cognitive state of patients for the clinician.
    33. (1989). Multilingual aphasia examination.
    34. (2005). Multiple frontal systems controlling response speed.
    35. (1995). Neuropsychological assessment. 3rd ed.
    36. (2000). Neuropsychological vulnerabilities in chronic alcoholism. In Noronha A, Eckardt MJ, Warren K (eds). Review of NIAAA’s neuroscience and behavioral research portfolio.
    37. (1999). Neuropsychology and neuroimaging of alcohol and illicit drug abuse. In Calev A (ed). Neuropsychological functions in psychiatric disorders.
    38. (1998). Nonhuman animal models of memory dysfunction in neurodegenerative disease. In Troster A (ed). Memory in neurodegenerative disease. NY:
    39. (1990). Object alternation and orbitofrontal system dysfunction in Alzheimer’s and Parkinson’s disease.
    40. (1998). Orbitofrontal function, object alternation and perseveration.
    41. (1967). Parkinsonism: onset, progression and mortality.
    42. (2001). Principles of neurology,
    43. (1994). Psychiatric Association.
    44. (1990). Regional cerebral blood fl ow in chronic alcoholics measured by single photon emission computerized tomography.
    45. (1986). Selective delayed response defi cits in Alzheimer’s and Parkinson’s disease.
    46. (1976). Surgical anatomy of the proximal anterior cerebral artery.
    47. (2004). The functions of the orbitofrontal cortex.
    48. (1993). The Halstead Reitan neuropsychological test battery: Theory and clinical interpretation.
    49. (1990). The nigrostriatal dopaminergic system assessed in vivo by positron emission tomography in healthy volunteer subjects and patients with Parkinson’s disease.
    50. (2004). The role of emotion in decision-making: Evidence from neurological patients with orbitofrontal damage. Brain and cognition (Special Issue: Development of orbitofrontal function),
    51. (1958). Validity of the Trail Making Test as an indicator of organic brain damage. Percept Mot Skills,
    52. (1984). Varieties of perseveration.
    53. (1997). Wechsler Adult Intelligence Scale-III.
    54. (1997). Wechsler Memory Scale-III.
    55. (1993). Wisconsin Card Sorting Test (WCST). Manual revised and expanded. Odessa, FL: Psychological Assessment Resources.
    56. (1993). Wisconsin Card Sorting Test as a measure of frontal pathology: A review.

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