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Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion Caused by Squamous Cell Carcinoma of the Nasopharynx: Case Report

By Minwook Yoo, Evelyn Oteng Bediako and Ozan Akca


The Paraneoplastic syndromes include the disorders that accompany benign or malignant tumors but are not directly related to mass effects or invasion by the primary tumor or its metastases. Neoplastic cells can produce a variety of peptides that exert biologic actions at local and distant sites and can elicit responses that cause a variety of hormonal, hematologic, dermatologic and neurologic symptoms. Almost every type of malignancy has the potential to produce hormones or cytokines or to induce immunologic responses. Lung cancers, both non-small cell and small cell, are capable of producing a variety of paraneoplastic syndromes. The majority of such syndromes are caused by small cell carcinomas, including many endocrinopathies. Syndrome of inappropriate antidiuretic hormone (SIADH) has been commonly associated with small cell carcinoma and is often seen in these patients. However, SIADH associated with squamous cell carcinoma has rarely been reported on, and the mechanism for this rare association is still unknown. We present here a case of a 77-yr-old man who developed SIADH caused by squamous cell carcinoma of the nasopharynx

Topics: Case Report
Publisher: Korean Society of Otorhinolaryngology-Head and Neck Surgery
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Provided by: PubMed Central
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    1. (1957). A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone.
    2. (1976). Boro ES. Antidiuretic hormone.
    3. (1963). Carcinoma of the lung with inappropriate antidiuresis. demonstration of antidiuretic-hormone-like activity in tumor extract.
    4. (1996). Elevated arginine vasopressin levels in squamous cell cancer of the head and neck.
    5. (2005). Hypothalamic-pituitary-adrenocortical axis regulation. Endocrinol Metab Clin North Am.
    6. (2004). Neuropeptide Y immunoreactivity and corticotropin-releasing hormone mRNA level are increased in the hypothalamus of mouse bearing a human oral squamous cell carcinoma. Neuropeptides.
    7. (1976). Pathophysiologic and pharmacologic alterations in the release and action of ADH. Metabolism.
    8. (1991). Syndrome of inappropriate antidiuretic hormone secretion in cancer of the head and neck. Ann Otol Rhinol Laryngol.
    9. (1992). Syndrome of inappropriate secretion of antidiuretic hormone in a patient with carcinoma of the nasopharynx.
    10. (1997). Syndrome of inappropriate secretion of antidiuretic hormone in nasopharynx carcinoma. Pediatr Nephrol.
    11. (1985). The human vasopressin gene is linked to the oxytocin gene and is selectively expressed in a cultured lung cancer cell line. J Biol Chem.
    12. (1997). The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) as a consequence of neck dissection. J Laryngol Otol.
    13. (1967). The syndrome of inappropriate secretion of antidiuretic hormone.

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