Skip to main content
Article thumbnail
Location of Repository

Moderately Differentiated Neuroendocrine Carcinoma of the Larynx

By Eun-Jae Chung, Seung-Kuk Baek, Soon-Young Kwon, Jung-Soo Woo and Kwang-Yoon Jung


Neuroendocrine neoplasm of the larynx is a morphologically heterogeneous group of tumors. This unusual neoplasm includes the four different type of tumors. Paraganglioma is the best-known neural origin tumor. The epithelial origin tumor is further divided based on the degree of differentiation into well, moderately, and poorly differentiated carcinoma. The diverse biological behavior of neuroendocrine neoplasm of larynx makes an accurate diagnosis of paramount importance, since treatment depends on diagnostic accuracy. The diagnosis is based primarily on light microscopy, and immunohistochemical and/or ultrastructural investigations are needed to diagnose correctly. The mainstay of treatment of moderately differentiated neuroendocrine carcinoma of the larynx is surgery. Elective neck treatment should be performed considering the high likelihood of cervical lymph node metastases. The 5-yr survival rate approximates 50%, and 10-yr survival rate is only 30%

Topics: Case Report
Publisher: Korean Society of Otorhinolaryngology-Head and Neck Surgery
OAI identifier:
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    1. (1998). A review of neuroendocrine neoplasms of the larynx: update on diagnosis and treatment. J Laryngol Otol.
    2. (2004). A study of moderately differentiated neuroendocrine carcinomas of the larynx and an examination of non-neoplastic larynx tissue for neuroendocrine cells. Laryngoscope.
    3. (1969). Carcinoid of the larynx. Arch Otolaryngol.
    4. (1999). Case study of well-differentiated carcinoid tumor of the larynx and review of laryngeal neuroendocrine tumors. Otolaryngol Head Neck Surg.
    5. (2005). Moderately differentiated neuroendocrine carcinoma (atypical carcinoid) of the larynx: a clinically aggressive tumor. Laryngoscope.
    6. (2003). moderately differentiated neuroendocrine tumor of the larynx: a brief report. Ear Nose Throat J.
    7. (2002). Neuroendocrine neoplasms of the larynx: diagnosis, treatment and prognosis. ORL J Otorhinolaryngol Relat Spec.
    8. (1995). Neuroendocrine tumors in various organ systems in a ten-year period. Eur J Surg Oncol.
    9. (1992). Neuroendocrine tumors of larynx. Ann Otol Rhinol Laryngol.
    10. (2005). The spectrum of endocrinocarcinomas of the larynx. Oral Oncol.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.