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Exotic Small Mammals as Potential Reservoirs of Zoonotic Bartonella spp.

By Kai Inoue, Soichi Maruyama, Hidenori Kabeya, Keiko Hagiya, Yasuhito Izumi, Yumi Une and Yasuhiro Yoshikawa


To evaluate the risk for emerging human infections caused by zoonotic Bartonella spp. from exotic small mammals, we investigated the prevalence of Bartonella spp. in 546 small mammals (28 species) that had been imported into Japan as pets from Asia, North America, Europe, and the Middle and Near East. We obtained 407 Bartonella isolates and characterized them by molecular phylogenetic analysis of the citrate synthase gene, gltA. The animals examined carried 4 zoonotic Bartonella spp. that cause human endocarditis and neuroretinitis and 6 novel Bartonella spp. at a high prevalence (26.0%, 142/546). We conclude that exotic small mammals potentially serve as reservoirs of several zoonotic Bartonella spp

Topics: Research
Publisher: Centers for Disease Control and Prevention
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Provided by: PubMed Central

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  2. Bartonella birtlesii sp. nov., isolated from small mammals (Apodemus spp.).
  3. (1997). Bartonella clarridgeiae, a newly recognized zoonotic pathogen causing inoculation papules, fever, and lymphadenopathy (cat scratch disease).
  4. Bartonella henselae and Bartonella elizabethae as potential canine pathogens.
  5. (2003). Bartonella infection in sylvatic small mammals of central Sweden. Epidemiol Infect.
  6. (2005). Bartonella species in rodents and shrews in the greater Jakarta area. Southeast Asian J Trop Med Public Health.
  7. (2004). Bartonella species isolated from rodents, Greece. Emerg Infect Dis.
  8. (2006). Bartonella spp. in pets and effect on human health. Emerg Infect Dis.
  9. Bartonella strains from ground squirrels are identical to Bartonella washoensis isolated from a human patient.
  10. (1998). Bartonella tribocorum sp. nov., a new Bartonella species isolated from the blood of wild rats.
  11. Bartonella vinsonii subsp. arupensis as an agent of blood culture–negative endocarditis in a human.
  12. (1985). Confi dence limits on phylogenies: An approach using the bootstrap. Evolution.
  13. (2009). Demonstration of Bartonella grahamii DNA in ocular fl uids of a patient with neuroretinitis.
  14. (1995). Differentiation of Bartonella–like isolates at the species level by PCR-restriction fragment length polymorphism in the citrate synthase gene.
  15. (1997). Distribution, diversity, and host specifi city of Bartonella in rodents from the Southeastern United States. Am J Trop Med Hyg.
  16. Diversity of bartonellae associated with small mammals inhabiting Free State province,
  17. fever, and splenomegaly caused by a newly recognized Bartonella species.
  18. Gene-sequence-based criteria for species defi nition in bacteriology: the Bartonella paradigm. Trends Microbiol.
  19. (2002). Genetic and ecologic characteristics of Bartonella communities in rodents in southern China. Am J Trop Med Hyg.
  20. (1994). Grahamella in small woodland mammals in the U.K.: isolation, prevalence and host specifi city. Ann Trop Med Parasitol.
  21. Isolation of a new subspecies, Bartonella vinsonii subsp. arupensis, from a cattle rancher: identity with isolates found in conjunction with Borrelia burgdorferi and Babesia microti among naturally infected mice.
  22. (1996). Isolation of Bartonella henselae from domestic cats in Japan. J Vet Med Sci.
  23. Isolation of Bartonella rattimassiliensis sp. nov. and Bartonella phoceensis sp. nov. from European Rattus norvegicus.
  24. (2007). MEGA4: Molecular Evolutionary Genetics Analysis (MEGA) software version 4.0. Mol Biol Evol.
  25. (2004). Prevalence and diversity of Bartonella in rodents of northern Thailand: a comparison with Bartonella in rodents from southern China. Am J Trop Med Hyg.
  26. Prevalence and genetic diversity of Bartonella species isolated from wild rodents in Japan. Appl Environ Microbiol.
  27. (1995). Proposals to unify the genera Grahamella and Bartonella, with descriptions of Bartonella talpae comb. nov.,
  28. (1999). Rats of the genus Rattus reservoir hosts for pathogenic Bartonella species: an Old World origin for a New World disease? J Infect Dis.
  29. (1993). Rochalimaea elizabethae sp. nov. isolated from a patient with endocarditis.
  30. (2006). Rodent-associated Bartonella febrile illness, southwestern United States. Emerg Infect Dis.
  31. (1999). Survey of Bartonella species infecting intradomicillary animals in the Huayllacallán Valley, Ancash, Peru, a region endemic for human bartonellosis. Am J Trop Med Hyg.
  32. (1997). The CLUSTAL_X windows interface: fl exible strategies for multiple sequence alignment aided by quality analysis tools. Nucleic Acids Res.
  33. (1987). The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol.

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