Skip to main content
Article thumbnail
Location of Repository

Muscle Microvascular Dysfunction in Central Obesity Is Related to Muscle Insulin Insensitivity but Is Not Reversed by High-Dose Statin Treatment

By Geraldine F. Clough, Magdalena Turzyniecka, Lara Walter, Andrew J. Krentz, Sarah H. Wild, Andrew J. Chipperfield, John Gamble and Christopher D. Byrne
Topics: Original Article
Publisher: American Diabetes Association
OAI identifier: oai:pubmedcentral.nih.gov:2671046
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2000). A: Evidence for physiological coupling of insulin-mediated glucose metabolism and limb blood flow.
    2. Advanced glycation end products: sparking the development of diabetic vascular injury.
    3. (2003). Blood flow and muscle metabolism: a focus on insulin action.
    4. (2007). Byrne CD: Differential effects of fatness, fitness and physical activity energy expenditure on whole-body, liver and fat insulin sensitivity. Diabetologia
    5. C: Effect of endurance training on muscle microvascular filtration capacity and vascular bed morphometry in the elderly.
    6. CD: Cortisol clearance and associations with insulin sensitivity, body fat and fatty liver in middle-aged men.
    7. CD: Grip strength and the metabolic syndrome: findings from the Hertfordshire Cohort Study.
    8. CD: Non-esterified fatty acid concentrations are independently associated with hepatic steatosis in obese subjects.
    9. E: Microcirculation and the metabolic syndrome.
    10. E: Physiologic hyperinsulinemia enhances human skeletal muscle perfusion by capillary recruitment.
    11. Effective osmotic pressure of the plasma proteins and other quantities associated with the capillary circulation in the hindlimbs of cats and dogs.
    12. (2009). EJ: Insulin sensitivity of muscle capillary recruitment in vivo.
    13. EJ: Microvascular recruitment is an early insulin effect that regulates skeletal muscle glucose uptake in vivo.
    14. (2006). EJ: Mixed meal and light exercise each recruit muscle capillaries in healthy humans.
    15. EJ: Obesity blunts insulin-mediated microvascular recruitment in human forearm muscle.
    16. Elisaf M: Targeting vascular risk in patients with metabolic syndrome but without diabetes.
    17. (2005). Evaluation of the Portable HealthWear Armband: a device to measure total daily energy expenditure in free-living type 2 diabetic individuals. Diabetes Care
    18. F: A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man.
    19. (1998). Gartside IB: Human calf precapillary resistance decreases in response to small cumulative increases in venous congestion pressure.
    20. (1996). H: Evidence for dissociation of insulin stimulation of blood flow and glucose uptake in human skeletal muscle: studies using [15O]H2O, [18F]fluoro-2-deoxy-D-glucose, and positron emission tomography. Diabetes
    21. Hudlicka O: Counterpoint: there is not capillary recruitment in active skeletal muscle during exercise.
    22. (2006). Impact of obesity and insulin resistance on vasomotor tone: nitric oxide and beyond. Clin Exp Pharmacol Physiol
    23. (2008). Impaired microvascular perfusion: a consequence of vascular dysfunction and a potential cause of insulin resistance in muscle.
    24. (1997). Intact insulin stimulation of skeletal muscle blood flow, its heterogeneity and redistribution, but not of glucose uptake in non-insulin-dependent diabetes mellitus.
    25. JC: Obesity and vascular dysfunction.
    26. KM: Microvascular endothelial function in subjects with type 2 diabetes and the effect of lipid-lowering therapy.
    27. Last word on Point:Counterpoint: there is/is not capillary recruitment in active skeletal muscle during exercise.
    28. Laufs U: Pleiotropic effects of statins.
    29. Modifications of microvascular filtration capacity in human limbs by training and electrical stimulation.
    30. Obesity, insulin resistance, and microvessel density.
    31. Onalan O: Evaluation of endothelial dysfunction: flow-mediated dilation.
    32. (1991). Pi-Sunyer FX: Effect of exercise training on insulin sensitivity and glucose metabolism in lean, obese, and diabetic men.
    33. PJ: Evidence of impaired microvascular function in pre-eclampsia: a non-invasive study. Clin Sci (Lond)
    34. PL: Vascular and metabolic response to statin in the mildly hypertensive hypercholesterolemic elderly.
    35. Point: there is capillary recruitment in active skeletal muscle during exercise.
    36. Rheological characteristics of erythrocytes incubated in glucose media.
    37. (1976). SL: Water filtration of the forearm in short- and long-term diabetes mellitus. Diabetologia
    38. Soeldner JS: Capillary permeability and blood flow in skeletal muscle of patients with diabetes mellitus and genetic prediabetes.
    39. Stehouwer CD: Direct evidence for insulin-induced capillary recruitment in skin of healthy subjects during physiological hyperinsulinemia.
    40. (2009). Stehouwer CD: Free fatty acid levels modulate microvascular function: relevance for obesity-associMUSCLE
    41. Stehouwer CD: Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers.
    42. The metabolic syndrome: a global public health problem and a new definition.
    43. (1994). Tooke JE: Capillary filtration coefficient in type II (non-insulin-dependent) diabetes.
    44. (1996). Tooke JE: Differences in microvascular fluid permeability between long-duration type I (insulin-dependent) diabetic patients with and without significant microangiopathy. Clin Sci (Lond)
    45. (2005). Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care
    46. Umpleby AM: Contrasting insulin sensitivity of endogenous glucose production rate in subjects with hepatocyte nuclear factor-1beta and -1alpha mutations.
    47. (2004). Veves A: Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care
    48. White NJ: Age-related changes in microvascular permeability: a significant factor in the susceptibility of children to shock? Clin Sci (Lond)

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.