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Non-Canonical Wnt Signaling and N-Cadherin Related β-Catenin Signaling Play a Role in Mechanically Induced Osteogenic Cell Fate

By Emily J. Arnsdorf, Padmaja Tummala and Christopher R. Jacobs
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2670536
Provided by: PubMed Central
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    1. (2000). A finite difference model of loadinduced fluid displacements within bone under mechanical loading.
    2. (2003). A model for mechanotransduction in bone cells: the load-bearing mechanosomes.
    3. (2003). Activated beta-catenin induces osteoblast differentiation of C3H10T1/2 cells and participates in BMP2 mediated signal transduction.
    4. (2007). Betacatenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation.
    5. (1999). Bone and hormonal changes induced by skeletal unloading in the mature male rat.
    6. (2007). Bone regeneration is regulated by wnt signaling.
    7. (2006). Bone strength: current concepts.
    8. (1996). Cadherin-catenin complex: protein interactions and their implications for cadherin function.
    9. (2000). Canalicular fluid flow induced by bending of a long bone.
    10. (2007). Canonical and non-canonical wnts differentially affect the development potential of primary isolate of human bone marrow mesenchymal stem cells.
    11. (2005). Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression.
    12. (2004). Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.
    13. (2005). Comparative genomics on Dkk1 orthologs.
    14. (2004). Convergence of Wnt, beta-catenin, and cadherin pathways.
    15. (2007). Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation.
    16. (2006). Cross-talk of WNT and FGF signaling pathways at GSK3beta to regulate beta-catenin and SNAIL signaling cascades.
    17. (2006). Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass.
    18. (1998). Differential effect of steady versus oscillating flow on bone cells.
    19. (2007). Direct interactions of Runx2 and canonical Wnt signaling induce FGF18.
    20. (2006). Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors.
    21. (2003). Diverse range of fixed positional deformities and bone growth restraint provoked by flaccid paralysis in embryonic chicks.
    22. (1999). E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation.
    23. (2005). Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells.
    24. (2002). Endostatin is a potential inhibitor of Wnt signaling.
    25. (1994). Expression and functional involvement of Ncadherin in embryonic limb chondrogenesis.
    26. (2005). FGF-20 and DKK1 are transcriptional targets of beta-catenin and FGF-20 is implicated in cancer and development.
    27. (2003). Fluid flowinduced prostaglandin E2 response of osteoblastic ROS 17/2.8 cells is gap junction-mediated and independent of cytosolic calcium.
    28. (2004). Fluid shear stress induces beta-catenin signaling in osteoblasts.
    29. (2002). High bone density due to a mutation in LDL-receptor-related protein 5.
    30. (1995). Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos.
    31. (2008). Inhibition of Wnt signaling by the osteoblast-specific transcription factor Osterix.
    32. (2007). Knocking down dickkopf-1 alleviates estrogen deficiency induction of bone loss. A histomorphological study in ovariectomized rats.
    33. KnotheTateML,SteckR,Forwood MR,Niederer P (2000)Invivodemonstration of load-induced fluid flow in the rat tibia and itspotential implicationsforprocesses associated with functional adaptation.
    34. (2001). LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development.
    35. (2004). LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.
    36. (2006). LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST.
    37. (2006). MAP kinase and calcium signaling mediate fluid flow-induced human mesenchymal stem cell proliferation.
    38. (2007). Mechanical loading by fluid shear stress enhances IGF-1 receptor signaling in osteoblasts in a PKCzeta-dependent manner.
    39. (2009). Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics.
    40. (1998). Mechanobiology of skeletal regeneration.
    41. (2001). Metastasisinducing dna regulates the expression of the osteopontin gene by binding the transcription factor Tcf-4.
    42. (2006). Molecular mechanism of osteochondroprogenitor fate determination during bone formation.
    43. (2007). Murine osteoblasts regulate mesenchymal stem cells via WNT and cadherin pathways: mechanism depends on cell-cell contact mode.
    44. (2009). N-cadherin interacts with axin and LRP5 to negatively regulate Wnt/beta-catenin signaling, osteoblast function, and bone formation.
    45. (2004). Oscillatory fluid flow affects human marrow stromal cell proliferation and differentiation.
    46. (2006). Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling.
    47. (2001). Osteopontin gene regulation by oscillatory fluid flow via intracellular calcium mobilization and activation of mitogen-activated protein kinase in MC3T3-E1 osteoblasts.
    48. (2006). Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase.
    49. (2006). Purified Wnt5a protein activates or inhibits betacatenin-TCF signaling depending on receptor context.
    50. (2008). Rac1 activation controls nuclear localization of beta-catenin during canonical Wnt signaling.
    51. (2007). Rac1 signaling stimulates N-cadherin expression, mesenchymal condensation, and chondrogenesis.
    52. (2006). Regulation of bone mass by Wnt signaling.
    53. (2002). Regulation of epithelial cell migration and tumor formation by beta-catenin signaling.
    54. (1989). Relationships between loading history and femoral cancellous bone architecture.
    55. (2006). RhoA acts downstream of Wnt5 and Wnt11 to regulate convergence and extension movements by involving effectors Rho kinase and Diaphanous: use of zebrafish as an in vivo model for GTPase signaling.
    56. (2006). RhoA/ROCK signaling regulates chondrogenesis in a context-dependent manner.
    57. (2005). RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.
    58. (2006). Role of canonical Wntsignalling in joint formation.
    59. (2007). Ror2, a novel modulator of osteogenesis.
    60. (2007). Signaling and transcriptional regulation in osteoblast commitment and differentiation.
    61. (1994). Spatiotemporal profile of N-cadherin expression in the developing limb mesenchyme.
    62. (1994). Stimulation of bone growth through sports. A radiologic investigation of the upper extremities in professional tennis players.
    63. (2009). Stromal cell-derived factor 1/CXCR4 signaling is critical for the recruitment of mesenchymal stem cells to the fracture site during skeletal repair in a mouse model.
    64. (2006). The control of chondrogenesis.
    65. (1986). The Law of Bone Remodeling.
    66. (1987). The mechanostat: a proposed pathogenic mechanism of osteoporoses and the bone mass effects of mechanical and nonmechanical agents.
    67. (2007). The orphan receptor tyrosine kinase Ror2 promotes osteoblast differentiation and enhances ex vivo bone formation.
    68. (2000). The Wnt/Ca2+ pathway: a new vertebrate Wnt signaling pathway takes shape.
    69. (1990). Toward an identification of mechanical parameters initiating periosteal remodeling: a combined experimental and analytic approach.
    70. (2006). Traction forces exerted through N-cadherin contacts.
    71. (2003). Transforming growth factor-beta-mediated chondrogenesis of human mesenchymal progenitor cells involves N-cadherin and mitogen-activated protein kinase and Wnt signaling cross-talk.
    72. (1988). Vital biomechanics: proposed general concepts for skeletal adaptations to mechanical usage.
    73. (2006). Who’s afraid of the big bad Wolff?: ‘‘Wolff’s law’’ and bone functional adaptation.
    74. (2006). Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.
    75. (2006). Wnt signaling activation during bone regeneration and the role of Dishevelled in chondrocyte proliferation and differentiation.
    76. (2006). Wnt signaling and osteoblastogenesis.
    77. (1997). Wnt signaling: a common theme in animal development.
    78. (2006). Wnt signaling: a key regulator of bone mass.
    79. (1996). Wnt-1 regulates free pools of catenins and stabilizes APC-catenin complexes.
    80. (2000). Wnt/frizzled-2 signaling induces aggregation and adhesion among cardiac myocytes by increased cadherin-beta-catenin complex.
    81. (2005). WNT/PCP signaling pathway and human cancer.
    82. (2000). Xwnt11 and the regulation of gastrulation in Xenopus.

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