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New insights into intra- and intermolecular interactions of immunoglobulins: crystal structure of mouse IgG2b-Fc at 2·1-Å resolution

By Petr Kolenko, Jan Dohnálek, Jarmila Dušková, Tereza Skálová, Renata Collard and Jindřich Hašek


The structure of the Fc fragment of monoclonal antibody IgG2b from hybridom M75 of Mus musculus has been determined by single crystal X-ray diffraction. This is the first report of the structure of the murine immunoglobulin isotype IgG2b. The structure refined at 2·1 Å resolution provides more detailed structural information about native oligosaccharides than was previously available. High-quality Fourier maps provide a clear identification of α-l-fucose with partial occupancy in the first branch of the antennary oligosaccharides. A unique Fc:Fc interaction was observed at the CH2-CH3 interface

Topics: Original Article
Publisher: Blackwell Science Inc
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Provided by: PubMed Central
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