Skip to main content
Article thumbnail
Location of Repository

A Structure-Based Approach to Ligand Discovery for 2C-Methyl-d-erythritol-2,4-cyclodiphosphate Synthase: A Target for Antimicrobial Therapy†

By Nicola L. Ramsden, Lori Buetow, Alice Dawson, Lauris A. Kemp, Venkatsubramanian Ulaganathan, Ruth Brenk, Gerhard Klebe and William N. Hunter
Publisher: American Chemical Society
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (1976). Biochemistry of polyisoprenoid biosynthesis.
  2. Biosynthesis of isoprenoids (carotenoids, sterols, prenyl side chains of chlorophylls, and plastoquinone) via a novel pyruvate/glyceraldehyde 3-phosphate non-mevalonate pathway in the green alga Scenedesmus obliquus.
  3. (2000). CO2 as main carbon source for isoprenoid biosynthesis via the mevalonate-independent methylerythritol 4-phosphate route in the marine diatoms Phaeodactylum tricornutum and Nitzschia oValis. Phytochemistry
  4. (2001). Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-Derythritol 4-phosphate pathway for isoprenoid biosynthesis.
  5. Identification of novel essential Escherichia coli genes conserved among pathogenic bacteria.
  6. (1993). Isoprenoid biosynthesis in bacteria: a novel pathway for the early steps leading to isopentenyl diphosphate.
  7. (2005). Multiple metabolic roles for the nonphotosynthetic plastid of the green alga Prototheca wickerhamii. Eukaryotic Cell
  8. (1999). Planting the seeds of new antimalarial drugs. Science
  9. (1999). The discovery of a mevalonate-independent pathway for isoprenoid biosynthesis in bacteria, algae and higher
  10. (2007). The non-mevalonate pathway of isoprenoid precursor biosynthesis.
  11. The non-mevalonate pathway of isoprenoids: genes, enzymes, and intermediates.
  12. (2000). The role of lateral gene transfer in the evolution of isoprenoid biosynthesis pathways.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.