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Genome-wide Association Study of Smoking Initiation and Current Smoking

By Jacqueline M. Vink, August B. Smit, Eco J.C. de Geus, Patrick Sullivan, Gonneke Willemsen, Jouke-Jan Hottenga, Johannes H. Smit, Witte J. Hoogendijk, Frans G. Zitman, Leena Peltonen, Jaakko Kaprio, Nancy L. Pedersen, Patrik K. Magnusson, Tim D. Spector, Kirsten Ohm Kyvik, Katherine I. Morley, Andrew C. Heath, Nicholas G. Martin, Rudi G.J. Westendorp, P. Eline Slagboom, Henning Tiemeier, Albert Hofman, Andre G. Uitterlinden, Yurii S. Aulchenko, Najaf Amin, Cornelia van Duijn, Brenda W. Penninx and Dorret I. Boomsma

Abstract

For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior

Topics: Article
Publisher: American Society of Human Genetics
OAI identifier: oai:pubmedcentral.nih.gov:2667987
Provided by: PubMed Central
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