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The overexpression of major antioxidant enzymes does not extend the lifespan of mice

By Viviana I Pérez, Holly Van Remmen, Alex Bokov, Charles J Epstein, Jan Vijg and Arlan Richardson

Abstract

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice

Topics: Short Take
Publisher: Blackwell Publishing Ltd
OAI identifier: oai:pubmedcentral.nih.gov:2667893
Provided by: PubMed Central
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