(2007). A combinatorial role for NFAT5 in both myoblast migration and differentiation during skeletal muscle myogenesis.
(2001). A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.
(2002). A DNA vector-based RNAi technology to suppress gene expression in mammalian cells.
(1997). Adipsic hypernatremia syndrome in infancy.
(2008). Analysis of the transcriptional activity of endogenous NFAT5 in primary cells using transgenic NFAT-luciferase reporter mice.
(2004). ATM, a DNA damageinducible kinase, contributes to activation by high NaCl of the transcription factor TonEBP/OREBP.
(2001). Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stress.
(2009). Brx mediates the response of lymphocytes to osmotic stress through the activation of NFAT5.
(2005). Buyukbese A
(2007). c-myb contributes to G2/M cell cycle transition in human hematopoietic cells by direct regulation of cyclin B1 expression.
(2004). Calcineurin/ NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy.
(2007). CalcineurinNFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.
(2007). Cellular response to hyperosmotic stresses.
(2006). Congenital progressive hydronephrosis (cph) is caused by an S256L mutation in aquaporin-2 that affects its phosphorylation and apical membrane accumulation.
(2008). Cyclin A/cdk2 coordinates centrosomal and nuclear mitotic events.
(2004). Cyclin B1 depletion inhibits proliferation and induces apoptosis in human tumor cells.
(2006). Cytometric assessment of histone H2AX phosphorylation: A reporter of DNA damage.
(2007). Degradation of NFAT5, a transcriptional regulator of osmotic stress-related genes, is a critical event for doxorubicin-induced cytotoxicity in cardiac myocytes.
(2006). Differential cellular distribution of tonicity-induced expression of transcription factor TonEBP in the rat brain following prolonged systemic hypertonicity.
(1991). Excessive hypernatremia in a patient with renal amyloid disease.
(2004). Expression of taurine transporter is regulated through the TonE (tonicity-responsive element)/ TonEBP (TonE-binding protein) pathway and contributes to cytoprotection in HepG2 cells.
(2002). Fyn and p38 signaling are both required for maximal hypertonic activation of the osmotic response element-binding protein/tonicity-responsive enhancer-binding protein (OREBP/TonEBP).
(2004). Gadd45 proteins induce G2/M arrest and modulate apoptosis in kidney cells exposed to hyperosmotic stress.
(2000). Generation and phenotype of mice harboring a nonsense mutation in the V2 vasopressin receptor gene.
(2000). Highefficiency deleter mice show that FLPe is an alternative to cre-loxP.
(2006). Hspa4ldeficient mice display increased incidence of male infertility and hydronephrosis development.
(2003). Hyperosmolar non-ketotic diabetic syndrome associated with rhabdomyolysis and acute renal failure: A case report and review of literature.
(2005). Hypertonic stress response.
(2008). Intracellular organic osmolytes: Function and regulation.
(1982). Living with water stress: Evolution of osmolyte systems.
(2004). Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression.
(2006). Mre11-Rad50-Nbs1 complex is activated by hypertonicity.
(1999). NFAT5, a constitutively nuclear NFAT protein that does not cooperate with fos and jun.
(2004). NFAT5/TonEBP mutant mice define osmotic stress as a critical feature of the lymphoid microenvironment.
(2002). NFATC2 transcription factor regulates cell cycle progression during lymphocyte activation: Evidence of its involvement in the control of cyclin gene expression.
(2004). Osmotic response element-binding protein (OREBP) is an essential regulator of the urine concentrating mechanism.
(2008). Osmotically-induced genes are controlled by the transcription factor TonEBP in cultured cardiomyocytes.
(1995). Prevention and management of hypernatremic dehydration in breast-fed infants.
(2000). Protection of renal inner medullary epithelial cells from apoptosis by hypertonic stress-induced p53 activation.
(2007). Proteomic identification of proteins associated with the osmoregulatory transcription factor TonEBP/OREBP: Functional effects of Hsp90 and PARP-1.
(1995). Rao A
(2004). Regulation of expression of the stress response gene, Osp94: Identification of the tonicity response element and intracellular signalling pathways.
(1993). Reversible vasopressin deficiency in severe hypernatremia.
(1998). Severely impaired urinary concentrating ability in transgenic mice lacking aquaporin-1 water channels.
(2002). Targeted disruption of hsp70.1 sensitizes to osmotic stress.
(1993). Targeted disruption of the MHC class II aa gene in C57BL/6 mice.
(2007). The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes.
(1999). The management of extreme hypernatraemia secondary to salt poisoning in an infant.
(2007). The NFAT1 transcription factor is a repressor of cyclin A2 gene expression.
(2002). The osmoprotective function of the NFAT5 transcription factor in T cell development and activation.
(2000). The TonE/TonEBP pathway mediates tonicity-responsive regulation of UT-A urea transporter expression.
(2004). TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
(2002). TonEBP/NFAT5 stimulates transcription of HSP70 in response to hypertonicity.
(1999). Tonicityresponsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicity.
(2004). Transcription factor tonicity-responsive enhancer-binding protein (TonEBP) which transactivates osmoprotective genes is expressed and upregulated following acute systemic hypertonicity in neurons in brain.
(2005). Transgenic mice expressing dominant-negative osmotic-response element-binding protein (OREBP) in lens exhibit fiber cell elongation defect associated with increased DNA breaks.
(1994). Tumor spectrum analysis in p53-mutant mice.