The electron capture dissociation (ECD) and collision-induced dissociation (CID) of complexes of polyamidoamine (PAMAM) dendrimers with metal ions Ag+, Cu2+, Zn2+, Fe2+, and Fe3+ were determined by Fourier transform ion cyclotron resonance mass spectrometry. Complexes were of the form [PD + M + mH]5+ where PD = generation two PAMAM dendrimer with amidoethanol surface groups, M = metal ion, m = 2–4. Complementary information regarding the site and coordination chemistry of the metal ions can be obtained from the two techniques. The results suggest that complexes of Fe3+ and Cu2+ are coordinated via both core tertiary amines, whereas coordination of Ag+ involves a single core tertiary amine. The Zn2+ and Fe2+ complexes do not appear to involve coordination by the dendrimer core
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