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Glutamine synthetase sequence evolution in the mycobacteria and their use as molecular markers for Actinobacteria speciation

By Don Hayward, Paul D van Helden and Ian JF Wiid
Topics: Research Article
Publisher: BioMed Central
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Provided by: PubMed Central

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  1. (1997). A: Isolation of the Corynebacterium glutamicum glnA gene encoding glutamine synthetase I. FEMS Microbiol Lett
  2. (2001). AD: Genetic architecture of thermal adaptation in Escherichia coli.
  3. (2005). All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol
  4. (1999). An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets. J Exp Med
  5. BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT.
  6. (1985). Confidence limits on phylogenies: an approach using the bootstrap. Evolution
  7. (2000). Cullimore JV: The presence of GSIlike genes in higher plants: support for the paralogous evolution of GSI and GSII genes.
  8. (2002). De Lisle GW: Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary-phase cultures.
  9. (1998). Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature
  10. (2007). Deschavanne P: Contribution of horizontally acquired genomic islands to the evolution of the tubercle bacilli. Mol Biol Evol
  11. (2003). DNA polymorphism analyses by the coalescent and other methods. Bioinformatics
  12. (2004). DR: Assessing the phylogeny of Frankia-actinorhizal plant nitrogen-fixing root nodule symbioses with Frankia 16S rRNA and glutamine synthetase gene sequences. Mol Phylogenet Evol
  13. (1989). DR: Physiological characteristics of glutamine synthetases I and II of Frankia sp. strain
  14. (1999). Dujon B: Pervasiveness of gene conservation and persistence of duplicates in cellular genomes.
  15. (2003). Enzymes with extra talents: moonlighting functions and catalytic promiscuity. C u r r O p i n C h e m B i o l
  16. (2006). Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions.
  17. (1994). Evolution of glutamine synthetase genes is in accordance with the neutral theory of molecular evolution.
  18. (2000). FM: Protein-coding genes as molecular markers for ecologically distinct populations: the case of two Bacillus species.
  19. (2003). Gascuel O: A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood. Syst Biol
  20. (2000). Genetic heterogeneity in Mycobacterium tuberculosis isolates reflected in IS6110 restriction fragment length polymorphism patterns as low-intensity bands.
  21. (2005). Gupta RS: Conserved indels in protein sequences that are characteristic of the phylum Actinobacteria.
  22. (2003). Horwitz MA: Inhibition of Mycobacterium tuberculosis glutamine synthetase as a novel antibiotic strategy against tuberculosis: demonstration of efficacy in vivo. Infect Immun
  23. (2004). Ikeo K: Evolutionary process of amino acid biosynthesis in Corynebacterium at the whole genome level. Mol Biol Evol
  24. (1998). Imanaka T: Sequence analysis of glutamate dehydrogenase (GDH) from the hyperthermophilic archaeon Pyrococcus sp. KOD1 and comparison of the enzymatic characteristics of native and recombinant GDHs. Mol Gen Genet
  25. (2006). Lengsin is a survivor of an ancient family of class I glutamine synthetases re-engineered by evolution for a role in the vertebrate lens. Structure
  26. (2006). mabileCuevas CF: Urban dust fecal pollution in Mexico City: antibiotic resistance and virulence factors of Escherichia coli.
  27. (1985). Magasanik B: Expression of glnA in Escherichia coli is regulated at tandem promoters.
  28. (2001). Massive gene decay in the leprosy bacillus. Nature
  29. (2000). NG: glnE is an essential gene in Mycobacterium tuberculosis.
  30. (1986). Novel subunit-subunit interactions in the structure of glutamine synthetase.
  31. (2006). Ottonello S: Structural and functional properties of lengsin, a pseudo-glutamine synthetase in the transparent human lens. Biochem Biophys Res Commun
  32. (2006). Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model. Infect Immun
  33. (2007). Reductive evolution and niche adaptation inferred from the genome of Mycobacterium ulcerans, the causative agent of Buruli ulcer. Genome Res
  34. (2000). Shinnick TM: Evaluation of Mycobacterium tuberculosis genes involved in resistance to killing by human macrophages. Infect Immun
  35. (1993). Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
  36. (2004). T: Genome sequence of Symbiobacterium thermophilum, an uncultivable bacterium that depends on microbial commensalism. Nucleic Acids Res
  37. (2006). Tartar A: Evolution of glutamine synthetase in heterokonts: evidence for endosymbiotic gene transfer and the early evolution of photosynthesis. Mol Biol Evol
  38. (1993). Tateno Y: Evolution of the glutamine synthetase gene, one of the oldest existing and functioning genes. Proc Natl Acad Sci USA
  39. (1998). The CspA family in Escherichia coli: multiple gene duplication for stress adaptation. Mol Microbiol
  40. (2001). The decaying genome of Mycobacterium leprae. Lepr Rev
  41. (2007). The Sorcerer II Global Ocean Sampling expedition: expanding the universe of protein families. PLoS Biol
  42. (1994). TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res
  43. (2006). Valpuesta JM: The three-dimensional structure of an eukaryotic glutamine synthetase: functional implications of its oligomeric structure.
  44. (2000). van Helden PD: Mapping of IS6110 flanking regions in clinical isolates of Mycobacterium tuberculosis demonstrates genome plasticity. Mol Microbiol
  45. (2002). van Helden PD: Multiple Mycobacterium tuberculosis strains in early cultures from patients in a high-incidence community setting.
  46. (1996). WB: Amplification of 16S rRNA genes from Frankia strains in root nodules of Ceanothus griseus, Coriaria arborea, Coriaria plumosa, Discaria toumatou, and Purshia tridentata. Appl Environ Microbiol
  47. (1997). WF: Archaea and the prokaryote-toeukaryote transition. Microbiol Mol Biol Rev
  48. (1994). WF: Evolutionary relationships of bacterial and archaeal glutamine synthetase genes.

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