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Reduced Incidence and Delayed Occurrence of Fatal Neoplastic Diseases in Growth Hormone Receptor/Binding Protein Knockout Mice

By Yuji Ikeno, Gene B. Hubbard, Shuko Lee, Lisa A. Cortez, Christie M. Lew, Celeste R. Webb, Darlene E. Berryman, Edward O. List, John J. Kopchick and Andrzej Bartke

Abstract

Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 deficiency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice

Topics: Journal of Gerontology: Biological Sciences
Publisher: Oxford University Press
OAI identifier: oai:pubmedcentral.nih.gov:2667132
Provided by: PubMed Central
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