Skip to main content
Article thumbnail
Location of Repository

AKT/eNOS signaling module functions as a potential feedback loop in the growth hormone signaling pathway

By Cong-Jun Li, Theodore H Elsasser and Stanislaw Kahl
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2666727
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2007). Cantley LC: AKT/PKB signaling: navigating downstream. Cell
    2. (1995). Carter-Su C: Growth hormone-promoted tyrosyl phosphorylation
    3. (2008). Carter-Su C: JAK2, but not Src family kinases, is required for STAT, ERK, and Akt signaling in response to growth hormone in preadipocytes and hepatoma cells. Mol Endocrinol
    4. (2001). Carter-Su C: Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab
    5. (2004). Carter-Su C: Tyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B beta. Mol Cell Biol
    6. (2007). Caveolae nitration of Janus kinase-2 at the 1007Y-1008Y site: coordinating inflammatory response and metabolic hormone readjustment within the somatotropic axis. Endocrinology
    7. (1991). Coordinate regulation of pp90rsk and a distinct protein-serine/threonine kinase activity that phosphorylates recombinant pp90rsk in vitro. Mol Cell Biol
    8. (2002). Cyclin-dependent kinase-1: linking apoptosis to cell cycle and mitotic catastrophe. Cell Death Differ
    9. (1999). DJ: Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt. Science
    10. (2007). Elsasser TH: Temporal response of liver signal transduction elements during in vivo endotoxin challenge in cattle: Effects of growth hormone treatment. Domest Anim Endocrinol
    11. (2003). et al.: Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells. Oncogene
    12. (1998). et al.: Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis.
    13. (2004). FJ: nitric oxide triggers the phosphatidylinositol 3-kinase/Akt survival pathway in insulin-producing RINm5F cells by arousing Src to activate insulin receptor substrate-1. Endocrinology
    14. (2007). Frank SJ: Role of the growth hormone (GH) receptor transmembrane domain in receptor predimerization and GH-induced activation. Mol Endocrinol
    15. (2004). From hormones to immunity: the physiology of immunology. Brain Behav Immun
    16. (1997). G: Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB. Nature
    17. (1996). Growth hormone and the immune response to bacterial infection. Horm Res
    18. (1968). Growth hormone and the metabolism of carbohydrate and lipid in adipose tissue.
    19. (2000). Growth hormone pulse-activated STAT5 signalling: a unique regulatory mechanism governing sexual dimorphism of liver gene expression. Novartis Found Symp
    20. (1996). Hemmings BA: Mechanism of activation of protein kinase B by insulin and IGF-1.
    21. (2000). Hetenyi L: Effect of growth hormone and inhibitors of protein kinase A on IGF-I, oxytocin and progesterone release by cultured bovine granulosa cells. Ann Endocrinol (Paris)
    22. (2000). Hetenyi L: The role of IGF-I, cAMP/protein kinase A and MAP-kinase in the control of steroid secretion, cyclic nucleotide production, granulosa cell proliferation and preimplantation embryo development in rabbits.
    23. (2004). Hwa V: New molecular mechanisms of GH resistance.
    24. (2002). JL: Growth hormone-induced differential desensitization of STAT5, ERK, and Akt phosphorylation.
    25. (2006). JL: Insulin enhances growth hormone induction of the MEK/ERK signaling pathway.
    26. (1999). Ketelslegers JM: Regulation of insulinlike growth factor-I in starvation and injury. Nutr Rev
    27. (2003). Kinetworks protein kinase multiblot analysis. Methods Mol Biol
    28. (1997). LC: PI3K: downstream AKTion blocks apoptosis. Cell
    29. (1997). Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway.
    30. (2004). Mechanisms underlying growth hormone effects in augmenting nitric oxide production and protein tyrosine nitration during endotoxin challenge. Endocrinology
    31. (2007). MG: The Akt-GSK-3 signaling cascade in the actions of dopamine. Trends Pharmacol Sci
    32. (2003). Mikulova E: Effect of GH and IGF-I treatment on reproduction, growth, and plasma hormone concentrations in domestic nutria (Myocastor coypus). Gen Comp Endocrinol
    33. (1991). Mitogen-activated Swiss mouse 3T3 RSK kinases I and II are related to pp44mpk from sea star oocytes and participate in the regulation of pp90rsk activity. Proc Natl Acad Sci USA
    34. (2005). Mitotic entry: a matter of oscillating destruction. Cell Cycle
    35. (2002). MJ: Role of Akt/protein kinase B in metabolism. Trends Endocrinol Metab
    36. (1999). Moelling K: Phosphorylation and regulation of Raf by Akt (protein kinase B). Science
    37. (1999). Nitric oxide and apoptosis. Vitam Horm
    38. (2007). Nuclear targeting of the growth hormone receptor results in dysregulation of cell proliferation and tumorigenesis. Proc Natl Acad Sci USA
    39. (1999). Pearson RB: The Akt kinase signals directly to endothelial nitric oxide synthase. Curr Biol
    40. (2006). RJ: New insights into growth hormone action.
    41. (2002). Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection. Curr Opin Clin Nutr Metab Care
    42. (2007). Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance. Biochim Biophys Acta
    43. (2007). Russo-Neustadt AA: Nitric oxide signaling participates in norepinephrine-induced activity of neuronal intracellular survival pathways. Life Sci
    44. (2008). Sata A, Ho KK: Growth hormone receptor modulators. Rev Endocr Metab Disord
    45. (2003). Sellers WR: PI3K/PTEN/AKT pathway. A critical mediator of oncogenic signaling. Cancer Treat Res
    46. (1999). Sessa WC: Regulation of endotheliumderived nitric oxide production by the protein kinase Akt. Nature
    47. (2005). Signaling mechanism for the insulin-like effects of growth hormone – another example of a classical hormonal negative feedback loop. Curr Drug Targets Immune Endocr Metabol Disord
    48. (2004). SJ: Caveolar and lipid raft localization of the growth hormone receptor and its signaling elements: impact on growth hormone signaling.
    49. (2004). SJ: Physical and functional interaction of growth hormone and insulin-like growth factor-I signaling elements. Mol Endocrinol
    50. (2008). The effect of chronic nitric oxide synthases inhibition on regulatory proteins in rat hearts. Mol Cell Biochem
    51. (2004). The glamour and gloom of glycogen synthase kinase-3. Trends Biochem Sci
    52. (2002). The protein kinase B/Akt signalling pathway in human malignancy. Cell Signal
    53. (2004). The structural basis for biological signaling, regulation, and specificity in the growth hormone-prolactin system of hormones and receptors. Adv Protein Chem
    54. (2007). WF: Growth hormone (GH)-associated nitration of Janus kinase-2 at the 1007Y-1008Y epitope impedes phosphorylation at this site: mechanism for and impact of a GH, AKT, and nitric oxide synthase axis on GH signal transduction. Endocrinology
    55. (1998). Woodgett JR: Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation.
    56. (1997). Zeiher AM: Nitric oxide and apoptosis: another paradigm for the double-edged role of nitric oxide. Nitric Oxide
    57. (1997). Zeiher AM: Suppression of apoptosis by nitric oxide via inhibition of interleukin-1betaconverting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J Exp Med

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.