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Unexpected Expression Pattern of Tetracycline-Regulated Transgenes in Mice

By M. Bao-Cutrona and P. Moral


In generating a conditional transgenic murine model based on a tetracycline-regulated system, we obtained unexpected patterns of expression due to the transcriptional inactivity of the tet-responder promoter. Here we show strong cell-type-restricted expression that was variegated to an extent determined by the number of responder transgene copies integrated into the host genome

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Publisher: Genetics Society of America
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Provided by: PubMed Central
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