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Neuronal Ca2+ signaling via caldendrin and calneurons

By Marina Mikhaylova, Yogendra Sharma, Carsten Reissner, Falko Nagel, Penmatsa Aravind, Bheemreddy Rajini, Karl-Heinz Smalla, Eckart D. Gundelfinger and Michael R. Kreutz

Abstract

AbstractThe calcium sensor protein caldendrin is abundantly expressed in neurons and is thought to play an important role in different aspects of synapto-dendritic Ca2+ signaling. Caldendrin is highly abundant in the postsynaptic density of a subset of excitatory synapses in brain and its distinct localization raises several decisive questions about its function. Previous work suggests that caldendrin is tightly associated with Ca2+- and Ca2+ release channels and might be involved in different aspects of the organization of the postsynaptic scaffold as well as with synapse-to-nucleus communication. In this report we introduce two new EF-hand calcium sensor proteins termed calneurons that apart from calmodulin represent the closest homologues of caldendrin in brain. Calneurons have a different EF-hand organization than other calcium sensor proteins, are prominently expressed in neurons and will presumably bind Ca2+ with higher affinity than caldendrin. Despite some significant structural differences it is conceivable that they are involved in similar Ca2+ regulated processes like caldendrin and neuronal calcium sensor proteins

Publisher: Elsevier B.V.
Year: 2006
DOI identifier: 10.1016/j.bbamcr.2006.08.047
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