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Targeted Delivery of Nucleic Acid-Based Therapeutics to the Pulmonary Circulation

By Ramalinga Kuruba, Annette Wilson, Xiang Gao and Song Li

Abstract

Targeted delivery of functional nucleic acids (genes and oligonucleotides) to pulmonary endothelium may become a novel therapy for the treatment of various types of lung diseases. It may also provide a new research tool to study the functions and regulation of novel genes in pulmonary endothelium. Its success is largely dependent on the development of a vehicle that is capable of efficient pulmonary delivery with minimal toxicity. This review summarizes the recent progress that has been made in our laboratory along these research directions. Factors that affect pulmonary nucleic acids delivery are also discussed

Topics: Emerging Drug Delivery Technologies
Publisher: Springer US
OAI identifier: oai:pubmedcentral.nih.gov:2664874
Provided by: PubMed Central
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