Skip to main content
Article thumbnail
Location of Repository

Promiscuous Aggregate-Based Inhibitors Promote Enzyme Unfolding

By Kristin E. D. Coan, David A. Maltby, Alma L. Burlingame and Brian K. Shoichet
Topics:
Publisher: American Chemical Society
OAI identifier: oai:pubmedcentral.nih.gov:2664636
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2002). A common mechanism underlying promiscuous inhibitors from virtual and highthroughput
    2. (2007). A high-throughput screen for aggregation-based inhibition in a large compound library.
    3. (2003). A specific mechanism of nonspecific inhibition.
    4. (2006). Avoiding physiochemical artifacts in early ADMETox experiments. Drug DiscoVery Today
    5. (2001). Changes in protein conformational mobility upon activation of extracellular regulated protein kinase-2 as detected by hydrogen exchange.
    6. (2005). Concentration and pH dependent aggregation of hydrophobic drug molecules and relevance to oral bioavailability.
    7. (2004). Detailed kinetic studies of an aggregating inhibitor. Inhibition of phosphomannomutase/ phosphoglucomutase by Disperse Blue 56. Biochemistry
    8. (1993). Determination of amide hydrogen exchange by mass spectrometry: a new tool for protein structure elucidation. Protein Sci.
    9. Development of a virtual screening method for identification of “frequent hitters” in compound libraries.
    10. (2003). Effect of detergent on “promiscuous” inhibitors.
    11. (2005). Effect of pH on thermaland chemical-induced denaturation of GFP.
    12. (1998). Exact and efficient analytical calculation of the accessible surface areas and their gradients for macromolecules.
    13. (1997). Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. AdV. Drug DeliVery ReV.
    14. High-throughput assays for promiscuous inhibitors.
    15. (2006). Hit discovery and hit-to-lead approaches. Drug DiscoVery Today
    16. (2006). Hydrogen exchange mass spectrometry for the analysis of protein dynamics.
    17. (2003). Identification and prediction of promiscuous aggregating inhibitors among known drugs.
    18. (1998). Identification of protein-protein interfaces by decreased amide proton solvent accessibility.
    19. (2006). Inhibition of kinesin motor proteins by adociasulfate-2.
    20. (2000). Inhibition of voltage-dependent sodium channels by Ro 31-8220, a ”specific” protein kinase inhibitor. FEBS Lett.
    21. (2003). Kinase inhibitors: not just for kinases anymore.
    22. (2004). Mass spectrometric approaches using electrospray ionization charge states and hydrogendeuterium exchange for determining protein structures and their conformational changes.
    23. (1998). Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry.
    24. (1996). Mechanisms and uses of hydrogen exchange.
    25. (2002). Molecular properties that influence the oral bioavailability of drug candidates.
    26. (2003). Nonleadlikeness and leadlikeness in biochemical screening. Drug DiscoVery Today
    27. (1997). Probing the non-covalent structure of proteins by amide hydrogen exchange and mass
    28. Pursuing the leadlikeness concept in pharmaceutical research.
    29. (1999). Recognizing molecules with druglike properties.
    30. Small-molecule aggregates inhibit amyloid polymerization.
    31. (2000). Specificity and mechanism of action of some commonly used protein kinase inhibitors.
    32. Stability and equilibria of promiscuous aggregates in high protein milieus.
    33. (2008). Stoichiometry and physical chemistry of promiscuous aggregate-based inhibitors.
    34. (1998). Structurebased enhancement of boronic acid-based inhibitors of AmpC betalactamase.
    35. (2001). Structures of ceftazidine and its transition-state analogue in complex with AmpC beta-lactamase: implications for resistance mutations and inhibitor design. Biochemistry
    36. (2008). Surface plasmon resonance based assay for the detection and characterization of promiscuous inhibitors.
    37. (2006). Targeting proteases: successes, failures and future prospects.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.