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Auditory Stimulation Dishabituates Olfactory Responses via Noradrenergic Cortical Modulation

By Jonathan J. Smith, Kiseko Shionoya, Regina M. Sullivan and Donald A. Wilson


Dishabituation is a return of a habituated response if context or contingency changes. In the mammalian olfactory system, metabotropic glutamate receptor mediated synaptic depression of cortical afferents underlies short-term habituation to odors. It was hypothesized that a known antagonistic interaction between these receptors and norepinephrine ß-receptors provides a mechanism for dishabituation. The results demonstrate that a 108 dB siren induces a two-fold increase in norepinephrine content in the piriform cortex. The same auditory stimulus induces dishabituation of odor-evoked heart rate orienting bradycardia responses in awake rats. Finally, blockade of piriform cortical norepinephrine ß-receptors with bilateral intracortical infusions of propranolol (100 μM) disrupts auditory-induced dishabituation of odor-evoked bradycardia responses. These results provide a cortical mechanism for a return of habituated sensory responses following a cross-modal alerting stimulus

Topics: Research Article
Publisher: Hindawi Publishing Corporation
OAI identifier:
Provided by: PubMed Central

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  1. (1976). A common presynaptic locus for the synaptic changes underlying short-term habituation and sensitization of the gillwithdrawal reflex in Aplysia,” Cold Spring Harbor Symposia on
  2. (2004). A.R.BestandD.A.Wilson,“Coordinatesynapticmechanisms contributing to olfactory cortical adaptation,”
  3. (1996). Activation of locus coeruleus enhances the responses of olfactory bulb mitral cells to weak olfactory nerve input,”
  4. Analysis of synaptic depression contributing to habituation of gill-withdrawal reflex in Aplysia californica,”
  5. (2005). Cortical metabotropic glutamate receptors contribute to habituation of a simple odor-evoked behavior,”
  6. (2001). Cyclic AMP-dependent protein kinase phosphorylates group III metabotropic glutamate receptors and inhibits their function as presynaptic receptors,”
  7. (2003). Deficits in prepulse inhibition and habituation in never-medicated, firstepisodeschizophrenia,”BiologicalPsychiatry,v ol.54,no .2,pp .
  8. (1989). Depletion of serotonin in the nervous system of Aplysia reduces the behavioral enhancement of gill withdrawal as well as the heterosynaptic facilitation produced by tail shock,”
  9. (2008). Distinct neural mechanisms mediate olfactory memory formation at different timescales,”
  10. (1996). Functional organization of olfactory system,”
  11. (1966). Habituation: a model phenomenonforthestudyofneuronalsubstratesofbehavior,”
  12. (2002). Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture,”
  13. Molecular biology of learning: modulation of transmitter release,”
  14. (1970). Neuronal correlates of habituation and dishabituation of the gill-withdrawal reflex in
  15. (2001). Ontogeny of odor discrimination: a method to assess novel odor discrimination
  16. (2006). R.D.Hawkins,T.E.Cohen,andE.R.Kandel,“Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization,”
  17. (1995). Rapid habituation of auditory responses of locus coeruleus cells in anaesthetized and awake rats,”
  18. (2002). S.BouretandS.J.Sara,“Locuscoeruleusactivationmodulates firing rate and temporal organization of odour-induced single-cell responses in rat piriform cortex,”
  19. (2004). Sensorimotor gating abnormalities in young males with fragile X syndrome and
  20. (1998). Synaptic correlates of odor habituation in the rat anterior piriform cortex,”
  21. (2004). The Rat Brain in Stereotaxic Coordinates,
  22. (2005). The role of metabotropic glutamate receptors and cortical adaptation in habituation of odor-guided behavior,”

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