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Caspase-independent type III programmed cell death in chronic lymphocytic leukemia: the key role of the F-actin cytoskeleton

By Sandrine Barbier, Laurent Chatre, Marlène Bras, Patricia Sancho, Gaël Roué, Clémence Virely, Victor J. Yuste, Sylvie Baudet, Manuel Rubio, Josep E. Esquerda, Marika Sarfati, Hélène Merle-Béral and Santos A. Susin

Abstract

Stimulation of the CD47 membrane receptor activates an original mechanism of cell death in chronic lymphocytic leukemia (CLL) cells that is caspase-independent. This study provides an exhaustive characterization of the CD47 anti-tumor signaling in CLL that may help to define new targets for further therapeutic strategies

Topics: Original Article
Publisher: Ferrata Storti Foundation
OAI identifier: oai:pubmedcentral.nih.gov:2663614
Provided by: PubMed Central
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