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Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

By Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele and Arjan A. van de Loosdrecht

Abstract

The response observed in some patients with myelodysplastic syndrome following treatment with antithymocyte globulin suggests that the immune system plays a role in at least some of these cases. This paper describes an activated adaptive immune system combined with autologous killer function of NK cells in patients with myelodysplastic syndromes. See related perspective article on page 449

Topics: Original Article
Publisher: Ferrata Storti Foundation
OAI identifier: oai:pubmedcentral.nih.gov:2663613
Provided by: PubMed Central
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