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Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

By Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele and Arjan A. van de Loosdrecht


The response observed in some patients with myelodysplastic syndrome following treatment with antithymocyte globulin suggests that the immune system plays a role in at least some of these cases. This paper describes an activated adaptive immune system combined with autologous killer function of NK cells in patients with myelodysplastic syndromes. See related perspective article on page 449

Topics: Original Article
Publisher: Ferrata Storti Foundation
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Provided by: PubMed Central
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