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Osteoblasts Express NLRP3, a Nucleotide-Binding Domain and Leucine-Rich Repeat Region Containing Receptor Implicated in Bacterially Induced Cell Death

By Samuel H McCall, Mahnaz Sahraei, Amy B Young, Charles S Worley, Joseph A Duncan, Jenny Pan-Yun Ting and Ian Marriott


Bacterially induced osteoblast apoptosis may be a major contributor to bone loss during osteomyelitis. We provide evidence for the functional expression in osteoblasts of NLRP3, a member of the NLR family of cytosolic receptors that has been implicated in the initiation of programmed cell death

Topics: Original Articles
Publisher: Amer Soc Bone & Mineral Res.
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Provided by: PubMed Central
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