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Effect of Micrometer-Scale Roughness of the Surface of Ti6Al4V Pedicle Screws in Vitro and in Vivo

By Zvi Schwartz, Perry Raz, Ge Zhao, Yael Barak, Michael Tauber, Hai Yao and Barbara D. Boyan


Background: Titanium implants that have been grit-blasted and acid-etched to produce a rough microtopography support more bone integration than do smooth-surfaced implants. In vitro studies have suggested that this is due to a stimulatory effect on osteoblasts. It is not known if grit-blasted and acid-etched Ti6Al4V implants also stimulate osteoblasts and increase bone formation clinically. In this study, we examined the effects of micrometer-scale-structured Ti6Al4V surfaces on cell responses in vitro and on tissue responses in vivo

Topics: Scientific Articles
Publisher: Journal of Bone and Joint Surgery, Inc
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Provided by: PubMed Central
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