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In Vitro Activities of Fluconazole and Voriconazole against Clinical Isolates of Candida spp. Determined by Disk Diffusion Testing in Turin, Italy▿

By Narcisa Mandras, Vivian Tullio, Valeria Allizond, Daniela Scalas, Giuliana Banche, Janira Roana, Francesca Robbiano, Giacomo Fucale, Aurelio Malabaila, Anna Maria Cuffini and Nicola Carlone


The in vitro activities of fluconazole and voriconazole against 1,024 clinical isolates of Candida spp. were determined by the agar disk diffusion test using the Clinical and Laboratory Standards Institute (CLSI) M44-A guidelines. The results of this investigation demonstrated the broad-spectrum in vitro activity of voriconazole, relative to that of fluconazole, against yeasts tested, in particular fluconazole-resistant isolates, such as Candida krusei that showed high susceptibility to voriconazole. The situation in Turin, Italy, is quite similar to that of the rest of Italy, reflecting the worldwide trend

Topics: Susceptibility
Publisher: American Society for Microbiology (ASM)
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Provided by: PubMed Central
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