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Detection of Human Immunodeficiency Virus (HIV) Type 1 M184V and K103N Minority Variants in Patients with Primary HIV Infection▿

By Thomas A. Toni, Eugene L. Asahchop, Daniela Moisi, Michel Ntemgwa, Maureen Oliveira, Bernard Masquelier, Bluma G. Brenner and Mark A. Wainberg

Abstract

We used an allele-specific real-time PCR assay to explore the presence of K103N and M184V minority species among primary human immunodeficiency virus (HIV) infections and their potential influence in HIV transmission. Thirty randomly chosen antiretroviral drug-naive patients lacking both the K103N and the M184V mutations as determined by conventional sequencing methods were studied, and K103N and M184V viral minority species were found in three (10%) and four (11%) patients, respectively

Topics: Antiviral Agents
Publisher: American Society for Microbiology (ASM)
OAI identifier: oai:pubmedcentral.nih.gov:2663097
Provided by: PubMed Central
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