Skip to main content
Article thumbnail
Location of Repository

Regulation of p110δ PI 3-Kinase Gene Expression

By Klaartje Kok, Gemma E. Nock, Elizabeth A. G. Verrall, Michael P. Mitchell, Daan W. Hommes, Maikel P. Peppelenbosch and Bart Vanhaesebroeck
Topics: Research Article
Publisher: Public Library of Science
OAI identifier: oai:pubmedcentral.nih.gov:2663053
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (1996). Acute Regulation by Insulin of Phosphatidylinositol-3-kinase, Rad, Glut 4, and Lipoprotein Lipase mRNA Levels in Human Muscle.
    2. (2004). Aligning multiple genomic sequences with the threaded blockset aligner.
    3. (2000). Analysis of the murine phosphoinositide 3-kinase gamma gene.
    4. (2003). Beta-catenin and Tcfs in mammary development and cancer.
    5. (2007). Beta-catenin/LEF-1 signalling in breast cancer–central players activated by a plethora of inputs.
    6. (2006). Cell target genes of Epstein-Barr virus transcription factor EBNA-2: induction of the p55alpha regulatory subunit of PI3-kinase and its role in survival of EREB2.5 cells.
    7. (2006). Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
    8. (1999). Characterizing the Interactions between the Two Subunits of the p101/p110gamma Phosphoinositide 3-Kinase and Their Role in the Activation of This Enzyme by Gbeta gamma Subunits.
    9. (2002). Chromatin remodeling, histone modifications, and DNA methylation-how does it all fit together?
    10. (2007). Class IA phosphoinositide 3-kinases are obligate p85-p110 heterodimers.
    11. (1995). Cloning and characterization of a G protein-activated human phosphoinositide3 kinase.
    12. (1993). Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
    13. (2002). Computational detection and location of transcription start sites in mammalian genomic DNA.
    14. (1995). Defective activation and survival of T cells lacking the Ets-1 transcription factor.
    15. (1997). Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.
    16. (1999). Defective regulation of phosphatidylinositol-3-kinase gene expression in skeletal muscle and adipose tissue of non-insulin-dependent diabetes mellitus patients.
    17. (2004). Differential regulation of the regulatory subunits for phosphatidylinositol 3-kinase in response to motor nerve injury.
    18. (2008). Divergent transcription from active promoters.
    19. (2002). Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase.
    20. (2007). Elucidating the altered transcriptional programs in breast cancer using independent component analysis.
    21. (1996). Enhanced gene expression for phosphatidylinositol 3-kinase in the hypoglossal motoneurons following axonal crush.
    22. (2008). Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis.
    23. (2006). Ets2 transcription factor in normal and neoplastic human breast tissue.
    24. (2005). Evolutionarily conserved elements in vertebrate, insect, worm, and yeast genomes.
    25. (2002). Expression of the transcription factor Ets-1 is an independent prognostic marker for relapse-free survival in breast cancer.
    26. (2000). Fli-1 is required for murine vascular and megakaryocytic development and is hemizygously deleted in patients with thrombocytopenia.
    27. (2004). Human placental growth hormone increases expression of the p85 regulatory unit of phosphatidylinositol 3-kinase and triggers severe insulin resistance in skeletal muscle.
    28. (2007). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project.
    29. (1991). Identification and characterization of a T-cellspecific enhancer adjacentto the murine CD4 gene. Mol Cell Biol11:
    30. (1995). Identification of a murine homolog of the human adenosine deaminase thymic enhancer.
    31. (2002). Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice.
    32. (2004). Impaired glucose-stimulated insulin secretion, enhanced intraperitoneal insulin tolerance, and increased beta-cell mass in mice lacking the p110gamma isoform of phosphoinositide 3-kinase.
    33. (1995). Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene.
    34. (2006). Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism.
    35. (2001). Inhibition of histone deacetylation induces constitutive derepression of the beta interferon promoter and confers antiviral activity.
    36. (2009). Khwaja A
    37. (1991). LEF-1, a gene encoding a lymphoid-specific protein with an HMG domain, regulates T-cell receptor alpha enhancer function [corrected].
    38. (2002). Lymphoid enhancer-binding factor-1 binds and activates the recombination-activating gene-2 promoter together with c-Myb and Pax-5 in immature B cells.
    39. (2005). MatInspector and beyond: promoter analysis based on transcription factor binding sites.
    40. (2008). Mechanisms underlying p53 regulation of PIK3CA transcription in ovarian surface epithelium and in ovarian cancer.
    41. (2008). miR-29 miRNAs activate p53 by targeting p85alpha and CDC42.
    42. (2008). Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters.
    43. (1994). NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.
    44. (1997). p110delta, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes.
    45. (1997). P110delta, a novel phosphoinositide 3-kinase in leukocytes.
    46. (2005). p84, a New G[beta][gamma]-Activated Regulatory Subunit of the Type IB Phosphoinositide 3-Kinase p110[gamma].
    47. (2005). Phosphoinositide 3-kinase gamma controls autonomic regulation of the mouse heart through Gi-independent downregulation of cAMP level.
    48. (2002). Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats.
    49. (1997). Phosphoinositide 3-kinases: a conserved family of signal transducers.
    50. (2004). PI3Kgamma modulates the cardiac response to chronic pressure overload by distinct kinase-dependent and -independent effects.
    51. Pourtier A (2008) Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment.
    52. (1999). Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase.
    53. (2005). Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kgamma.
    54. (1997). PU.1 functions in a cell-autonomous manner to control the differentiation of multipotential lymphoid-myeloid progenitors.
    55. (1992). RAG-1-deficient mice have no mature B and T lymphocytes.
    56. (1992). RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement.
    57. (2001). Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes.
    58. (2003). Regulation of breast cancer cell chemotaxis by the phosphoinositide 3-kinase p110delta.
    59. (2006). Regulation of epidermal homeostasis and repair by phosphoinositide 3-kinase.
    60. (2008). Regulation of phosphoinositide 3-kinase expression in health and disease. Trends Biochem Sci Accepted for publication.
    61. (1999). Retinoic acid induces selective expression of phosphoinositide 3-kinase gamma in myelomonocytic U937 cells.
    62. (2008). RNA exosome depletion reveals transcription upstream of active human promoters.
    63. (1999). Role of nuclear factor of activated T cells (NFAT) in the expression of interleukin-5 and other cytokines involved in the regulation of hemopoetic cells.
    64. (2006). Role of phosphatidylinositol 3-kinasegamma in the beta-cell: interactions with glucagonlike peptide-1.
    65. (2007). SREBP1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55gamma. J Lipid Res.
    66. (2005). Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition.
    67. (2005). Stimulatory cross-talk between NFAT3 and estrogen receptor in breast cancer cells.
    68. (2001). Structural organization of the mouse phosphatidylinositol 3-kinase p110d gene.
    69. (2001). Synthesis and function of 3-phosphorylated inositol lipids.
    70. (2008). The antisense transcriptomes of human cells.
    71. (2008). The forkhead transcription factor FOXO3a increases PI3K/Akt activity in drug-resistant leukaemic cells through induction of PIK3CA expression.
    72. (1997). The G[beta][gamma] Sensitivity of a PI3K Is Dependent upon a Tightly Associated Adaptor,
    73. (2007). The interferon regulatory factor family in host defense: mechanism of action.
    74. (2007). The IRF family, revisited.
    75. (2008). The noncoding RNA, miR-126, suppresses the growth of neoplastic cells by targeting phosphatidylinositol 3-kinase signaling and is frequently lost in colon cancers. Genes Chromosomes Cancer.
    76. (1999). The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter.
    77. (2008). The p110beta isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110gamma.
    78. (2005). The role of endothelial PI3Kgamma activity in neutrophil trafficking.
    79. (2008). The role of LEF/TCF factors in neoplastic transformation.
    80. (2003). The UCSC Genome Browser Database.
    81. (2008). Transcription. Gene expression–where to start?
    82. (2008). Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.
    83. (1994). Transcriptional regulation of T-cell genes during T-cell development.
    84. (1998). Transcriptional regulation of vav, a gene expressed throughout the hematopoietic compartment.
    85. (2001). Translating the histone code.
    86. (2001). Tumour biology. Weakening link to colorectal cancer?
    87. (2005). Upregulated function of phosphatidylinositol-3-kinase in genetically hypertensive rats: a moderator of arterial hypercontractility.
    88. (1998). Use of RDA analysis of knockout mice to identify myeloid genes regulated in vivo by PU.1 and C/EBPalpha.
    89. (1997). Yolk sac angiogenic defect and intra-embryonic apoptosis in mice lacking the Ets-related factor TEL.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.