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A prime/boost DNA/Modified vaccinia virus Ankara vaccine expressing recombinant Leishmania DNA encoding TRYP is safe and immunogenic in outbred dogs, the reservoir of zoonotic visceral leishmaniasis

By Connor Carson, Maria Antoniou, Maria Begoña Ruiz-Argüello, Antonio Alcami, Vasiliki Christodoulou, Ippokratis Messaritakis, Jenefer M. Blackwell and Orin Courtenay

Abstract

Previous studies demonstrated safety, immunogenicity and efficacy of DNA/modified vaccinia virus Ankara (MVA) prime/boost vaccines expressing tryparedoxin peroxidase (TRYP) and Leishmania homologue of the mammalian receptor for activated C kinase (LACK) against Leishmania major challenge in mice, which was consistent with results from TRYP protein/adjuvant combinations in non-human primates. This study aimed to conduct safety and immunogenicity trials of these DNA/MVA vaccines in dogs, the natural reservoir host of Leishmania infantum, followed-up for 4 months post-vaccination

Topics: Article
Publisher: Elsevier Science
OAI identifier: oai:pubmedcentral.nih.gov:2663027
Provided by: PubMed Central
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