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Alteration of Fibroblast Architecture and Loss of Basal Lamina Apertures in Human Emphysematous Lung

By Faye E. Sirianni, Alireza Milaninezhad, Fanny S. F. Chu and David C. Walker


Rationale: In normal human lung, single alveolar fibroblasts link capillary endothelium to type 2 pneumocytes through apertures in the endothelial and epithelial basal laminae. These fibroblasts are hypothesized to play a role in cellular communication between the endothelium and epithelium and are positioned to provide leukocytes a surface on which they may migrate through the interstitium

Topics: B. Chronic Obstructive Pulmonary Disease
Publisher: American Thoracic Society
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Provided by: PubMed Central
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