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Relative Corticosteroid Insensitivity of Peripheral Blood Mononuclear Cells in Severe Asthma

By Mark Hew, Pankaj Bhavsar, Alfons Torrego, Sally Meah, Nadia Khorasani, Peter J. Barnes, Ian Adcock and Kian Fan Chung

Abstract

Rationale and Objectives: Patients with severe asthma have a poor therapeutic response to corticosteroid therapy, and corticosteroid responsiveness cannot be easily measured in these patients. We hypothesized that this poor response is associated with a reduced effect of corticosteroids to inhibit cytokine release from activated peripheral blood mononuclear cells (PBMCs)

Topics: B. Asthma and Allergy
Publisher: American Thoracic Society
OAI identifier: oai:pubmedcentral.nih.gov:2662905
Provided by: PubMed Central
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