Skip to main content
Article thumbnail
Location of Repository

The high affinity selectin glycan ligand C2-O-sLex and mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

By Catherine A St Hill, Mariya Farooqui, Gregory Mitcheltree, H Evin Gulbahce, Jose Jessurun, Qing Cao and Bruce Walcheck
Topics: Research Article
Publisher: BioMed Central
OAI identifier: oai:pubmedcentral.nih.gov:2662873
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles

    Citations

    1. (2001). A: Heparin and cancer revisited: mechanistic connections involving platelets, P-selectin, carcinoma mucins, and tumor metastasis. Proc Natl Acad Sci USA
    2. (2004). A: Microsatellite instability and survival rate in the solid or nonsolid types of poorly differentiated colorectal adenocarcinoma. Int Surg
    3. (2003). AFM: Assumptionfree analysis of quantitative real-time polymerase chain reaction (PCR) data. Neurosci Lett
    4. (1992). BK: The three members of the selectin receptor family recognize a common carbohydrate epitope, the sialyl Lewis(x) oligosaccharide.
    5. (1994). Brockhausen I: Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology
    6. (1997). Carcinoma-associated expression of core 2 β-1,6-N-acetylglucosaminyltransferase gene in human colorectal cancer: role of O-glycans in tumor progression. Cancer Res
    7. (1985). Cell surface glycoconjugates as onco-differentiation markers in hematopoietic cells. Biochim Biophys Acta
    8. (2000). Cell surface molecules and their prognostic values in assessing colorectal carcinomas. Ann Surg
    9. (2006). CJ: Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand.
    10. (2001). Clinicopathological significance of core 2 β1,6-N-acetylglucosaminyltransferase messenger RNA expressed in the pulmonary adenocarcinoma determined by in situ hybridization. Cancer Res
    11. (1993). Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis x to adhesion of human cancer cells to vascular endothelium. Cancer Res
    12. (2000). Control of O-glycan branch formation. Molecular cloning and characterization of a novel thymusassociated core 2 beta1, 6-n-acetylglucosaminyltransferase.
    13. (2001). Core 2 β1,6-N-acetylglucosaminyltransferases and α1,3-fucosyltransferases regulate the synthesis of O-glycans on selectin ligands on oral cavity carcinoma cells. APMIS
    14. (1997). DL: Endothelial-selectin ligands sialyl Lewis(x) and sialyl Lewis(a) are differentiation antigens immunogenic in human melanoma. Cancer
    15. (1986). DM S: Prognostic indicators of colon tumors: the Gastrointestinal Tumor Study Group experience. Cancer
    16. (1993). DM: Colorectal cancer metastasis determined by carbohydrate-mediated cell adhesion: role of sialyl-Lex antigens. Semin Cancer Biol
    17. (1994). DM: Langerhans' cell expression of the selectin ligand, sialyl Lewis x. Immunology
    18. e l t a r e a c t i o n B Normal Well Moderate Poor Differentiation status of tumor F o l d c h a n g e i n C G n T a bBMC Cancer 2009, 9:79 http://www.biomedcentral.com/1471-2407/9/79 Page 13 of 14 (page number not for citation purposes)
    19. (1993). Eijnden DH van den: Human myeloid alpha 3-fucosyltransferase is involved in the expression of the sialyl-Lewis(x) determinant, a ligand for E- and P-selectin. Blood
    20. (2000). Endothelial and epithelial expression of sialyl Lewis x in squamous carcinoma of the tongue. APMIS
    21. (1997). Endothelial and epithelial expression of sialyl Lewis(x) and sialyl Lewis(a) in lesions of breast carcinoma.
    22. (1990). Endothelial leukocyte adhesion molecule 1: direct expression cloning and functional interactions. Proc Natl Acad Sci USA
    23. (1996). Eselectin binds to squamous cell carcinoma and keratinocyte cell lines.
    24. (1992). Expression cloning of a cDNA encoding UDP-GlcNAc:Gal beta 1-3-GalNAc-R (GlcNAc to GalNAc) beta 1-6GlcNAc transferase by gene transfer into CHO cells expressing polyoma large tumor antigen. Proc Natl Acad Sci USA
    25. (1996). GA: An improved ELISA for the determination of sialyl Lewis(x) structures on purified glycoconjugates.
    26. (1999). H: Control of O-glycan branch formation. Molecular cloning of human cDNA encoding a novel beta1,6-N-acetylglucosaminyltransferase forming core 2 and core 4.
    27. (2006). Hsu S-M: C2GnT-M is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene
    28. (2000). Human colon cancer cells express multiple glycoprotein ligands for E-selectin.
    29. (1993). Immunohistochemical expression of sialyl Lex antigen in relation to survival of patients with colorectal carcinoma. Cancer
    30. (1993). Inflammation-induced expression of sialyl Lewis X-containing glycan structures on alpha 1-acid glycoprotein (orosomucoid) in human sera.
    31. (1998). Inflammation-induced expression of sialyl LewisX is not restricted to alpha1-acid glycoprotein but also occurs to a lesser extent on alpha1-antichymotrypsin and haptoglobin.
    32. (1996). Irimura T: Carbohydrate antigens in carcinoma invasion and metastasis. Nippon Geka Gakkai Zasshi
    33. (1995). Irimura T: Characterization of human colon carcinoma variant cells selected for sialyl Lex carbohydrate antigen: liver colonization and adhesion to vascular endothelial cells. Exp Cell Res
    34. (1997). Irimura T: Expression of carbohydrate antigen sialyl Le(a): a new functional prognostic factor in gastric cancer.
    35. (1989). Irimura T: Increased expression of sialyl-dimeric Lex antigen in liver metastases of human colorectal carcinoma. Cancer Res
    36. (1997). Irimura T: Involvement of carbohydrate antigen sialyl Lewis(x) in colorectal cancer metastasis. Dis Colon Rectum
    37. (1996). JC: Enhanced sialylation of mucin-associated carbohydrate structures in human colon cancer metastasis. Gastroenterology
    38. (2004). KR: Functional analysis of the combined role of the O-linked branching enzyme core 2 beta1-6-N-glucosaminyltransferase and dimerization of Pselectin glycoprotein ligand-1 in rolling on P-selectin.
    39. (2001). Libutti SK: General aspects of anti-angiogenesis and cancer therapy. Expert Opin Biol Ther
    40. (1989). MP: An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science
    41. (1995). MP: Differential colon cancer cell adhesion to E-, P-, and L-selectin: role of mucin-type glycoproteins. Cancer Res
    42. (1998). oligosaccharide biosynthesis distinguishes between selectin ligands essential for leukocyte homing and inflammation. Immunity
    43. (1993). Orr FW: Adhesion molecules and their role in cancer metastasis. Cell Biophys
    44. (1996). Phenotypes correlating to metastatic properties of pancreas adenocarcinoma in vivo: the importance of surface sialyl Lewis(a) antigen.
    45. (1999). RD: A novel glycosulfopeptide binds to P-selectin and inhibits leukocyte adhesion to Pselectin.
    46. (2003). RD: Model glycosulfopeptides from P-selectin glycoprotein ligand-1 require tyrosine sulfation and a core 2-branched O-glycan to bind to L-selectin.
    47. (2000). RD: Noncovalent association of P-selectin glycoprotein ligand-1 and minimal determinants for binding to P-selectin.
    48. (1990). Recognition by ELAM-1 of the sialyl-Lex determinant on myeloid and tumor cells. Science
    49. (1996). RP: Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and E-selectin.
    50. (1996). RP: Post-translational modifications of recombinant P-selectin glycoprotein ligand-1 required for binding to P- and Eselectin.
    51. (2002). RP: The monclonal antibody CHO-131 binds to a core 2 O-glycan terminated with sialylLewis x, which is a functional glycan ligand for P-selectin. Blood
    52. (1999). RP: Tyrosine replacement in P-selectin glycoprotein ligand-1 affects distinct kinetic and mechanical properties of bonds with P- and L-selectin. Proc Natl Acad Sci USA
    53. (1983). S-l: A granulocyte reactive monoclonal antibody, 1G10, identifies the Gal/3-4 (Fuc a 1-3) GlcNAc (X determinant) expressed in HL-60 cells on both glycolipid and glycoprotein molecules. Blood
    54. (1992). S: Endothelial leukocyte adhesion molecule-1-dependent adhesion of colon carcinoma cells to vascular endothelium is inhibited by an antibody to Lewis fucosylated type 1 carbohydrate chain. Lab Invest
    55. (2001). Severe impairment of leukocyte rolling in v enu l es o f co r e 2 g l ucosaminyltransferase-deficient mice. Blood
    56. Slanetz CA: Pattern and significance of lymphatic spread from cancer of the colon and rectum.
    57. (1995). Takagi H: Expression of E-selectin on endothelial cells of small veins in human colorectal cancer.
    58. (2001). The relative activities of the C2GnT1 and ST3Gal-I glycosyltransferases determine O-glycan structure and expression of a tumor-associated epitope on MUC1.
    59. (1996). Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism. Cancer Res
    60. (1988). Uhlenbruck G: Biosynthesis of the cancer-associated sialyl-Lex determinant in human amniotic fluid. Biol Chem Hoppe-Seyler
    61. (1999). Varki A: Distinct selectin ligands on colon carcinoma mucins can mediate pathological interactions among platelets, leukocytes, and endothelium.
    62. (1998). Varki A: P-selectin deficiency attenuates tumor growth and metastasis.
    63. (2002). Varki A: Synergistic effects of L-and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
    64. (2005). Walcheck B: Expression of the high-affinity selectin glycan ligand C2-O-sLeX by colon carcinoma cells. Cancer Lett
    65. (2006). Walcheck B: The monoclonal antibody CHO-131 identifies a subset of cutaneous lymphocyteassociated antigen T cells enriched in P-selectin-binding cells.
    66. (1997). Wolitzky BA: Liver endothelial E-selectin mediates carcinoma cell adhesion and promotes liver metastasis.
    67. (1994). YS: E-selectin binding by pancreatic tumor cells is inhibited by cancer sera.

    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.