Skip to main content
Article thumbnail
Location of Repository

Mechanotherapy: how physical therapists’ prescription of exercise promotes tissue repair

By K M Khan and A Scott


Mechanotransduction is the physiological process where cells sense and respond to mechanical loads. This paper reclaims the term “mechanotherapy” and presents the current scientific knowledge underpinning how load may be used therapeutically to stimulate tissue repair and remodelling in tendon, muscle, cartilage and bone

Topics: Reviews
Publisher: BMJ Publishing Group
OAI identifier:
Provided by: PubMed Central

Suggested articles


  1. (2008). The effectiveness of active exercise as an intervention for functional ankle instability: A systematic review. Sports Med
  2. (2006). Is there evidence to support the use of eccentric strengthening exercises to decrease pain and increase function in patients with patellar tendinopathy? Phys Ther
  3. Effectiveness of exercise therapy: A bestevidence summary of systematic reviews.
  4. Progressive resistance exercise in physical therapy: A summary of systematic reviews.
  5. (1995). Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int
  6. Electric fields and bone loss of disuse.
  7. Early responses to mechanical load in tendon: Role for calcium signaling, gap junctions and intercellular communication.
  8. Mechanical signals and IGF-I gene splicing in vitro in relation to development of skeletal muscle.
  9. (2007). Mechanotransduction in striated muscle via focal adhesion kinase. Biochem Soc Trans
  10. Activation of stress-activated protein kinases (SAPK) in tendon cells following cyclic strain: The effects of strain frequency, strain magnitude, and cytosolic calcium.
  11. (2007). The molecular biology of tendinopathy: signaling and response pathways in tenocytes, in tendinopathy in athletes.
  12. Connexin 32 and 43 gap junctions differentially modulate tenocyte response to cyclic mechanical load.
  13. (2008). Regulation of chondrocytic gene expression by biomechanical signals. Crit Rev Eukaryot Gene Expr
  14. (2002). Molecular biology of the cell.
  15. (1997). Geometric control of cell life and death.
  16. (1998). Integrin binding and mechanical tension induce movement of mRNA and ribosomes to focal adhesions.

To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.