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Inhibition of flucloxacillin tubular renal secretion by piperacillin

By Cornelia B Landersdorfer, Carl M J Kirkpatrick, Martina Kinzig, Jürgen B Bulitta, Ulrike Holzgrabe and Fritz Sörgel


WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTMost β-lactams are excreted by filtration and to a greater extent by tubular secretion, which is a capacity-limited saturable pathway.Pharmacokinetic interactions between co-administered β-lactams have been frequently reported; however, their mechanism and possible clinical benefits are not well defined.We are not aware of the interaction between piperacillin and flucloxacillin being reported in the literature

Topics: Drug Interactions
Publisher: Blackwell Science Inc
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Provided by: PubMed Central
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