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Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study

By Yan Feng, Bruce G Pollock, Kim Coley, Stephen Marder, Del Miller, Margaret Kirshner, Manickam Aravagiri, Lon Schneider and Robert R Bies


WHAT IS ALREADY KNOWN ABOUT THIS SUBJECTRisperidone metabolism is affected by blocking CYP2D6 and CYP3A4 (in CYP2D6 poor metabolizers) metabolizing enzymes.Age affects risperidone disposition and renal function affects elimination of 9-hydroxy-risperidone (primary active metabolite)

Topics: Pharmacokinetics
Publisher: Blackwell Science Inc
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Provided by: PubMed Central
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