Skip to main content
Article thumbnail
Location of Repository

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival

By Mohamed Lamkanfi, Lilian O. Moreira, Patrudu Makena, Diana C. J. Spierings, Kelli Boyd, Peter J. Murray, Douglas R. Green and Thirumala-Devi Kanneganti

Abstract

Extensive apoptosis of leukocytes during sepsis and endotoxic shock constitutes an important mechanism linked to the excessive mortality associated with these disorders. Caspase inhibitors confer protection from endotoxin-induced lymphocyte apoptosis and improve survival, but it is not clear which caspases mediate lipopolysaccharide (LPS)–induced lymphocyte apoptosis and mortality. We report here that the apoptotic executioner caspase-7 was activated in the splenocytes of LPS-injected mice, suggesting a role for caspase-7 in lymphocyte apoptosis. Indeed, caspase-7–deficient mice were resistant to LPS-induced lymphocyte apoptosis and were markedly protected from LPS-induced lethality independently of the excessive production of serum cytokines. These results reveal for the first time a nonredundant role for caspase-7 in vivo and identify caspase-7 inhibition as a component of the mechanism by which caspase inhibitors protect from endotoxin-induced mortality

Topics: Immunobiology
Publisher: American Society of Hematology
OAI identifier: oai:pubmedcentral.nih.gov:2661861
Provided by: PubMed Central
Download PDF:
Sorry, we are unable to provide the full text but you may find it at the following location(s):
  • http://www.pubmedcentral.nih.g... (external link)
  • Suggested articles


    To submit an update or takedown request for this paper, please submit an Update/Correction/Removal Request.