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Homozygous CDA*3 is a major cause of life-threatening toxicities in gemcitabine-treated Japanese cancer patients

By H Ueno, N Kaniwa, T Okusaka, M Ikeda, C Morizane, S Kondo, E Sugiyama, S R Kim, R Hasegawa, Y Saito, T Yoshida, N Saijo and J Sawada


Among 242 Japanese pancreatic cancer patients, three patients (1.2%) encountered life-threatening toxicities, including myelosuppression, after gemcitabine-based chemotherapies. Two of them carried homozygous CDA*3 (CDA208G>A [Ala70Thr]), and showed extremely low plasma cytidine deaminase activity and gemcitabine clearance. Our results suggest that homozygous *3 is a major factor causing gemcitabine-mediated severe adverse reactions among the Japanese population

Topics: Clinical Studies
Publisher: Nature Publishing Group
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Provided by: PubMed Central

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