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Enhanced generalization of auditory conditioned fear in juvenile mice

By Wataru Ito, Bing-Xing Pan, Chao Yang, Siddarth Thakur and Alexei Morozov


Increased emotionality is a characteristic of human adolescence, but its animal models are limited. Here we report that generalization of auditory conditioned fear between a conditional stimulus (CS+) and a novel auditory stimulus is stronger in 4–5-wk-old mice (juveniles) than in their 9–10-wk-old counterparts (adults), whereas nonassociative sensitization induced by foot shock (US) and the ability to discriminate CS+ from an explicitly unpaired stimulus (CS−) are not dependent on age. These results suggest that aversive associations are less precise in juvenile mice and can more easily produce conditional responses to stimuli different from CS+. Yet, through the explicit unpairing of CS− from US during training, juveniles are able to overcome this greater fear generalization and learn that CS− is not associated with foot shock

Topics: Research
Publisher: Cold Spring Harbor Laboratory Press
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Provided by: PubMed Central
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